Imaginary Ribozymes.

ACS Chemical Biology
Ronald R Breaker

Abstract

Biocatalysis is dominated by protein enzymes, and only a few classes of ribozymes are known to contribute to the task of promoting biochemical transformations. The RNA World theory encompasses the notion that earlier forms of life made use of a much greater diversity of ribozymes and other functional RNAs to guide complex metabolic states long before proteins had emerged in evolution. In recent years, the discoveries of various classes of ribozymes, riboswitches, and other noncoding RNAs in bacteria have provided additional support for the hypothesis that RNA molecules indeed have the catalytic competence to promote diverse chemical reactions without the aid of protein enzymes. Herein, some of the most striking observations made from examinations of natural riboswitches that bind small ligands are highlighted and used as a basis to imagine the characteristics and functions of long-extinct ribozymes from the RNA World.

References

Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S A BennerA Tauer
Sep 1, 1995·Current Biology : CB·I Hirao, A D Ellington
Jun 1, 1997·Chemistry & Biology·J Tang, R R Breaker
Jan 23, 1999·Current Opinion in Structural Biology·J L Smith
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·G A Soukup, R R Breaker
Mar 29, 2000·Nucleic Acids Research·M P Robertson, A D Ellington
Jun 29, 2000·Annual Review of Biochemistry·D S Wilson, J W Szostak
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·P HeikinheimoA Goldman
Dec 6, 2002·BMC Biotechnology·Kristin M ThompsonAndrew D Ellington
Mar 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Brooke A Murphy McDanielTina M Henkin
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Vitaly EpshteinEvgeny Nudler
May 21, 2003·RNA·Narasimhan SudarsanRonald R Breaker
Jul 19, 2003·RNA·Gail Mitchell EmilssonRonald R Breaker
Aug 12, 2003·Nature Structural Biology·Wade C WinklerRonald R Breaker
Oct 7, 2003·Annual Review of Biochemistry·Peter B Moore, Thomas A Steitz
Mar 19, 2004·Nature·Wade C WinklerRonald R Breaker
Apr 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey E BarrickRonald R Breaker
Jun 3, 2004·Nature Reviews. Molecular Cell Biology·Maumita Mandal, Ronald R Breaker
Feb 24, 2006·Nature Structural & Molecular Biology·Ryan T FuchsTina M Henkin
Jul 1, 2006·Nature·Rebecca K Montange, Robert T Batey
Apr 20, 2007·Chemistry & Biodiversity·Xi ChenAndrew D Ellington
Dec 15, 2007·Genes & Development·Jennifer A CollinsWade C Winkler
Jan 22, 2008·Nature Structural & Molecular Biology·Sunny D GilbertRobert T Batey
Apr 30, 2008·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Joy Xin Wang, Ronald R Breaker
Sep 23, 2008·Nature Structural & Molecular Biology·Changrui LuAilong Ke
Mar 21, 2009·Annual Review of Biochemistry·Adam Roth, Ronald R Breaker
Jul 20, 2010·Structure·Colby D StoddardRobert T Batey
Aug 27, 2010·Cold Spring Harbor Perspectives in Biology·Michael P Robertson, Gerald F Joyce
Sep 17, 2010·Cold Spring Harbor Perspectives in Biology·Adrian R Ferré-D'Amaré, William G Scott
Nov 26, 2010·Cold Spring Harbor Perspectives in Biology·Ronald R Breaker

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Citations

Jan 27, 2021·Nature Chemical Biology·Shanker S S Panchapakesan, Ronald R Breaker
Mar 2, 2021·Chemical Society Reviews·Luke K McKenzieMarcel Hollenstein
Mar 22, 2021·The Journal of Biological Chemistry·Eric Westhof, Neocles B Leontis
May 6, 2021·Wiley Interdisciplinary Reviews. RNA·Timothy J Wilson, David M J Lilley
Jun 25, 2021·Nature Communications·Laurin FlemmichRonald Micura
Jul 15, 2021·Microbiology and Molecular Biology Reviews : MMBR·Eugene V KooninVadim I Agol

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