Imaging Amyloidopathy in Parkinson Disease and Parkinsonian Dementia Syndromes

Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging
Kirk A Frey, Myria Petrou

Abstract

Dementia arising in patients with Parkinson disease or parkinsonian neurodegeneration comprises a heterogeneous neuropathology. Clinical labeling of patients with both dementia and Parkinson disease is dichotomous, depending on the temporal development of cognitive impairment and motor parkinsonism. Patients with dementia arising first (or within the first year of PD) are classified as dementia with Lewy bodies; patients with PD for more than one year before cognitive decline are classified as Parkinson disease with dementia. Despite this differential clinical classification, autopsy studies demonstrate variable admixtures of cortical synuicleinopathy, Aβ-amyloidopathy and tau neurofibrillary tangle deposition. There are no routine clinical diagnostic measures that accurately distinguish the underlying neuropathologies in individual patients. In the present paper, we review the published literature describing characteristics of fibrillary Aβ-amyloid deposition on the basis of PET radiotracer imaging in patients with Parkinson disease and in parkinsonian dementia syndromes. Although individual reports often include only small-to-modest subject numbers, there is overall suggestion that PD patients have a lower incidence of Aβ-amy...Continue Reading

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Citations

Sep 22, 2015·Expert Review of Clinical Immunology·Bryan Paul Morgan
Sep 19, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Neha ShahNicolaas I Bohnen
Dec 22, 2015·Seminars in Nuclear Medicine·Laura B EisenmengerJames M Mountz
Aug 16, 2017·Current Neurology and Neuroscience Reports·Nicolaas I BohnenKirk A Frey
Jul 1, 2019·Journal of Alzheimer's Disease : JAD·Giovanni PalermoRoberto Ceravolo

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