Imaging and curcumin delivery in pancreatic cancer cell lines using PEGylated α-Gd2(MoO4)3 mesoporous particles

Dalton Transactions : an International Journal of Inorganic Chemistry
G Seeta Rama RajuJae Su Yu

Abstract

Mesoporous particles are emerging as multifunctional biomaterials for imaging and drug delivery in several disease models, including cancer. We developed PEGylated α-Gd2(MoO4)3 marigold flower-like mesoporous particles for the purpose of drug delivery and, more specifically, evaluated their ability to deliver curcumin. The obtained mesoporous particles significantly conjugated the curcumin particles on their surfaces by inducing the formation of curcumin nanoparticles. In vitro studies of the PEGylated mesoporous particles filled with curcumin demonstrated that these particles could considerably facilitate the continuous and sustained release of curcumin into the cytoplasm and nucleus. As a result, the intracellular release of curcumin can inhibit proliferation in two human pancreatic cancer cell lines: MIA PaCa-2 and PANC-1. Additionally, the particles showed the increased inhibition of pIKKα, pIKKα/β and NF-κB-DNA binding activity as compared to pure curcumin. The curcumin conjugated mesoporous particles are concentrated in the cytoplasm and nucleus of the treated cancer cell lines. Consequently, these mesoporous particles are an effective method for drug delivery that can cross the biological barriers of the body targeting t...Continue Reading

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Citations

Sep 10, 2014·International Journal of Molecular Sciences·Tao LiangJianying Pei
Nov 28, 2014·International Journal of Molecular Sciences·Katarzyna M TerlikowskaSlawomir J Terlikowski
Jul 16, 2014·ACS Applied Materials & Interfaces·Aifei WangGuangshan Zhu
Feb 24, 2016·International Journal of Pharmaceutics·Dominique Duchêne, Ruxandra Gref
Aug 4, 2015·Chemical Communications : Chem Comm·G Seeta Rama RajuJae Su Yu
Feb 28, 2015·Chemical Communications : Chem Comm·Hongmin SuGuangshan Zhu
Dec 5, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·G Seeta Rama RajuJae Su Yu
Jun 24, 2017·Physical Chemistry Chemical Physics : PCCP·Meiqi ChangHaifeng Zou
Aug 28, 2019·Seminars in Cancer Biology·Paola AielloIlaria Peluso
Feb 6, 2020·Seminars in Cancer Biology·Eunus S AliMohammad S Mubarak
Dec 25, 2019·Seminars in Cancer Biology·Haroon KhanHamed Mirzaei
Dec 24, 2019·Seminars in Cancer Biology·Mohammed Razeeth Shait MohammedMohammad Imran Khan
Jun 21, 2021·Seminars in Cancer Biology·Bala Prabhakar GirishGanji Seeta Rama Raju

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