PMID: 32154536DOI: 10.1039/d0cc00524jMar 11, 2020Paper
Imaging and therapeutic applications of Zn(ii)-cryptolepine-curcumin molecular probes in cell apoptosis detection and photodynamic therapy
Chemical Communications : Chem Comm
Qi-Pin QinHong Liang
Abstract
Novel red Zn(ii) complex-based fluorescent probes featuring cryptolepine-curcumin derivatives, namely, [Zn(BQ)Cl2] (BQ-Zn) and [Zn(BQ)(Cur)]Cl (BQCur-Zn), were developed for the simple and fluorescent label-free detection of apoptosis, an important biological process. The probes could synergistically promote mitochondrion-mediated apoptosis and enhance tumor therapeutic effects in vitro and vivo.
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Citations
Dec 29, 2020·Bioorganic & Medicinal Chemistry·Li-Qin QinHong Liang
Jan 27, 2021·Journal of Agricultural and Food Chemistry·Yong-Jia ChenChen Tang
Apr 30, 2021·European Journal of Medicinal Chemistry·Arnab BhattacharyyaAkhil R Chakravarty
May 6, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Yan YangHong Liang
Sep 4, 2021·Photodiagnosis and Photodynamic Therapy·Sevda ZeinaliFatma Yurt
Sep 29, 2021·Chemical Reviews·Thanh Chung PhamJuyoung Yoon
Synthesis and biological evaluation of mixed-ligand cyclometalated iridium(III)-quinoline complexes.
Nov 4, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Yan YangHong Liang
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Methods Mentioned
BETA
biosensing
confocal microscopy
flow cytometry
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Apoptosis
Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis
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