Imaging and therapeutic applications of Zn(ii)-cryptolepine-curcumin molecular probes in cell apoptosis detection and photodynamic therapy

Chemical Communications : Chem Comm
Qi-Pin QinHong Liang

Abstract

Novel red Zn(ii) complex-based fluorescent probes featuring cryptolepine-curcumin derivatives, namely, [Zn(BQ)Cl2] (BQ-Zn) and [Zn(BQ)(Cur)]Cl (BQCur-Zn), were developed for the simple and fluorescent label-free detection of apoptosis, an important biological process. The probes could synergistically promote mitochondrion-mediated apoptosis and enhance tumor therapeutic effects in vitro and vivo.

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Citations

Dec 29, 2020·Bioorganic & Medicinal Chemistry·Li-Qin QinHong Liang
Jan 27, 2021·Journal of Agricultural and Food Chemistry·Yong-Jia ChenChen Tang
Apr 30, 2021·European Journal of Medicinal Chemistry·Arnab BhattacharyyaAkhil R Chakravarty
Nov 4, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Yan YangHong Liang

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Methods Mentioned

BETA
biosensing
confocal microscopy
flow cytometry

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis