Imaging and therapy of ovarian cancer: clinical application of nanoparticles and future perspectives

Theranostics
Giovanni Di LorenzoStefania Biffi

Abstract

Despite significant advances in cancer diagnostics and treatment, ovarian cancers (OC) continue to kill more than 150,000 women every year worldwide. Due to the relatively asymptomatic nature and the advanced stage of the disease at the time of diagnosis, OC is the most lethal gynecologic malignancy. The current treatment for advanced OC relies on the synergistic effect of combining surgical cytoreduction and chemotherapy; however, beside the fact that chemotherapy resistance is a major challenge in OC management, new imaging strategies are needed to target microscopic lesions and improve both cytoreductive surgery and patient outcomes. In this context, nanostructured probes are emerging as a new class of medical tool that can simultaneously provide imaging contrast, target tumor cells, and carry a wide range of medicines resulting in better diagnosis and therapeutic precision. Herein we summarize several exemplary efforts in nanomedicine for addressing unmet clinical needs.

Citations

Oct 3, 2018·International Journal of Molecular Sciences·Guang-Jer Wu
Feb 15, 2019·Cell Structure and Function·Shan SuJu Chen
Apr 9, 2019·Expert Opinion on Drug Delivery·Stefania BiffiPaola Secchiero
Jul 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rommy TeranJorge Heredia-Moya
Aug 15, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Christian SecaCiro Isidoro
Jan 19, 2020·Cancers·Jonathan M PantshwaViness Pillay
Dec 24, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chao YangHaitao Ran
Aug 9, 2020·Cancer Management and Research·Yuanqi HeYue Li
Aug 9, 2020·International Journal of Nanomedicine·Barbara BortotStefania Biffi
Jan 7, 2020·Mini Reviews in Medicinal Chemistry·Kajal GhosalSudit Mukherjee
Mar 4, 2021·Journal of Nanoscience and Nanotechnology·Sergio MurgiaClaudia Caltagirone

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Methods Mentioned

BETA
imaging techniques
hysterectomy
fluorescence imaging
transfection
xenografts
xenograft

Clinical Trials Mentioned

NCT02110277
NCT02530606
NCT03304210
NCT02646319

Software Mentioned

IOTA

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