Imaging Assessment of Hepatic Changes after Fontan Surgery

International Heart Journal
Jinyoung SongJi Hye Kim

Abstract

The aim of this study was to evaluate hepatic dysfunction over 10 years following Fontan surgery. We assessed the clinical usefulness of diagnostic tools for the detection and follow-up of hepatic dysfunction in patients with Fontan circulation.A total of 26 post-Fontan patients (median age 13 years, range 10-35 years; median duration from Fontan procedure 10.5 years, range 4-17 years) were enrolled in this study. Hepatic assessment was performed by ultrasonography, computed tomography (CT), and transient elastography (TE) with biochemical tests, echocardiography, and cardiac catheterization. Related parameters were compared on the basis of different findings in liver sonography, CT, and TE.Liver CT and TE showed abnormal findings in all patients. Liver ultrasonography revealed abnormal results in 24 patients (92.3%). However, liver function test was normal and did not correlate with imaging studies. C-reactive protein was significantly correlated with severity of CT findings. White blood cell, platelet count, and N-terminal pro-brain natriuretic peptide were correlated with severity on TE. Post-Fontan high pulmonary vascular resistance (P = 0.046) and high mean pulmonary artery pressure (P = 0.046) correlated with hepatic chan...Continue Reading

References

May 1, 1975·The Annals of Thoracic Surgery·G G LindesmithB W Meyer
May 1, 1971·Thorax·F Fontan, E Baudet
Apr 6, 1999·Journal of Hepatology·C AubéP Calès
Sep 10, 2002·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Hisham TchelepiEdward Grant
Dec 31, 2003·Ultrasound in Medicine & Biology·Laurent SandrinRobert Palau
Sep 29, 2006·Heart·Christoph H KiesewetterGruschen R Veldtman
Oct 30, 2007·Journal of Clinical Pathology·T J KendallJ P Iredale
Mar 12, 2008·Alimentary Pharmacology & Therapeutics·P WittersD Cassiman
Jun 25, 2008·The Annals of Thoracic Surgery·Sonia CamposilvanLorenzo D'Antiga
Aug 19, 2011·BMC Gastroenterology·Ancha BaranovaZobair M Younossi
Oct 1, 2011·The Journal of Thoracic and Cardiovascular Surgery·Matthew C SchwartzElizabeth B Rand
Oct 12, 2012·Pediatric Radiology·Daniel B Wallihan, Daniel J Podberesky
Jul 16, 2013·International Journal of Cardiology·Robert W ElderWendy M Book
May 16, 2014·The Journal of Thoracic and Cardiovascular Surgery·Byung Won YooSeung Up Kim
Dec 24, 2014·The American Journal of Cardiology·Ian LindsayAnji T Yetman
Mar 20, 2015·International Heart Journal·Yasuo Ono, Norie Mitsushita
Apr 13, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Fred M WuAntonio R Perez-Atayde
Mar 15, 2016·European Journal of Radiology·Jung Min BaeJi Hye Kim

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.