Imaging Brain Mechanisms of Functional Somatic Syndromes: Potential as a Biomarker?

The Tohoku Journal of Experimental Medicine
Michiko KanoShin Fukudo

Abstract

When patients present with persistent bodily complaints that cannot be explained by a symptom-linked organic pathology (medically unexplained symptoms), they are diagnosed with 'functional' somatic syndromes (FSS). Despite their prevalence, the management of FSS is notoriously challenging in clinical practice. This may be because FSS are heterogeneous disorders in terms of etiopathogenesis. They include patients with primarily peripheral dysfunction, primarily centrally driven somatic symptoms, and a mix of both. Brain-imaging studies, particularly data-driven pattern recognition methods using machine learning algorithms, could provide brain-based biomarkers for these clinical conditions. In this review, we provide an overview of our brain imaging data on brain-body interactions in one of the most well-known FSS, irritable bowel syndrome (IBS), and discuss the possible development of a brain-based biomarker for FSS. Anticipation of unpredictable pain, which commonly elicits fear in FSS patients, induced increased activity in brain areas associated with hypervigilance during rectal distention and non-distention conditions in IBS. This was coupled with dysfunctional inhibitory influence of the medial prefrontal cortex (mPFC) and ...Continue Reading

References

Jan 17, 2002·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·E E Benarroch
Jul 20, 2002·Current Rheumatology Reports·Roland Staud
Sep 11, 2003·Current Opinion in Neurobiology·A D Craig
Jul 5, 2005·Nature Reviews. Neuroscience·Brent A Vogt
Dec 13, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·V AndresenH Mönnikes
Apr 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Heather L UrryRichard J Davidson
Mar 21, 2007·Lancet·Peter HenningsenWolfgang Herzog
Nov 16, 2007·Journal of Personality Assessment·Mark A LumleyAmanda J Burger
Jan 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steven M BermanEmeran A Mayer
Apr 21, 2010·Journal of Psychosomatic Research·Lineke M Tak, Judith G M Rosmalen
Oct 1, 2010·Experimental Biology and Medicine·Andreas Stengel, Yvette Taché
Dec 9, 2010·The American Journal of Gastroenterology·Douglas A Drossman
Mar 8, 2011·The American Journal of Gastroenterology·Brennan M R SpiegelLin Chang
Jul 29, 2011·European Journal of Clinical Investigation·Jo NijsLuc S De Clerck
Aug 7, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S E Kim, L Chang
Jan 11, 2013·BioPsychoSocial Medicine·Michiko Kano, Shin Fukudo
Feb 9, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michiko KanoSteven J Coen
Mar 16, 2013·The Journal of Pain : Official Journal of the American Pain Society·Randy NeblettRobert J Gatchel
Apr 12, 2013·The New England Journal of Medicine·Tor D WagerEthan Kross
May 3, 2013·Brain Topography·Philippe GoffauxKevin Whittingstall
May 31, 2013·Nature Reviews. Neuroscience·M Catherine BushnellLucie A Low
Jun 12, 2013·Journal of Consulting and Clinical Psychology·Brjánn LjótssonErik Hedman

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