Imaging brain tumour microstructure

NeuroImage
Markus NilssonPia C Sundgren

Abstract

Imaging is an indispensable tool for brain tumour diagnosis, surgical planning, and follow-up. Definite diagnosis, however, often demands histopathological analysis of microscopic features of tissue samples, which have to be obtained by invasive means. A non-invasive alternative may be to probe corresponding microscopic tissue characteristics by MRI, or so called 'microstructure imaging'. The promise of microstructure imaging is one of 'virtual biopsy' with the goal to offset the need for invasive procedures in favour of imaging that can guide pre-surgical planning and can be repeated longitudinally to monitor and predict treatment response. The exploration of such methods is motivated by the striking link between parameters from MRI and tumour histology, for example the correlation between the apparent diffusion coefficient and cellularity. Recent microstructure imaging techniques probe even more subtle and specific features, providing parameters associated to cell shape, size, permeability, and volume distributions. However, the range of scenarios in which these techniques provide reliable imaging biomarkers that can be used to test medical hypotheses or support clinical decisions is yet unknown. Accurate microstructure imagi...Continue Reading

Citations

Dec 19, 2018·Journal of Magnetic Resonance Imaging : JMRI·Bart R J van DijkenAnouk van der Hoorn
Mar 5, 2019·Insights Into Imaging·Roberto García-FigueirasHerbert Alberto Vargas
May 31, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Filip SzczepankiewiczMarkus Nilsson
Sep 14, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Markus NilssonPia C Sundgren
Oct 8, 2019·Journal of Neurotrauma·Sara H AndreasenHartwig R Siebner
Mar 7, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Björn LampinenMarkus Nilsson
Mar 18, 2020·Brain Structure & Function·Davy Charles VanderweyenDavid Fortin
Nov 27, 2020·Journal of Neuroscience Methods·Filip SzczepankiewiczMarkus Nilsson
Dec 22, 2020·Current Pathobiology Reports·Mehran BaboliSungheon Gene Kim
Jul 22, 2020·Journal of Neuroscience Methods·Ileana O JelescuKurt G Schilling
Mar 25, 2021·NeuroImage·Alexander GermanFrederik Bernd Laun
Aug 20, 2020·Journal of Neuroscience Methods·Kouhei KamiyaShigeki Aoki

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