Imaging Cancer Cells Expressing the Folate Receptor with Carbon Dots Produced from Folic Acid

Chembiochem : a European Journal of Chemical Biology
Susanta BhuniaRaz Jelinek

Abstract

Development of new imaging tools for cancer cells in vitro and in vitro is important for advancing cancer research, elucidating drug effects upon cancer cells, and studying cellular processes. We showed that fluorescent carbon dots (C-dots) synthesized from folic acid can serve as an effective vehicle for imaging cancer cells expressing the folate receptor on their surface. The C-dots, synthesized through a simple one-step process from folic acid as the carbon source, exhibited selectivity towards cancer cells displaying the folate receptor, making such cells easily distinguishable in fluorescence microscopy imaging. Biophysical measurements and competition experiments both confirmed the specific targeting and enhanced uptake of C-dots by the folate receptor-expressing cells. The folic acid-derived C-dots were not cytotoxic, and their use in bioimaging applications could aid biological studies of cancer cells, identification of agonists/antagonists, and cancer diagnostics.

References

Jun 2, 2005·Nature Materials·Igor L MedintzHedi Mattoussi
Jul 25, 2007·Angewandte Chemie·Haipeng LiuChengde Mao
Nov 26, 2008·Nature Medicine·Yasuteru UranoHisataka Kobayashi
Aug 19, 2009·International Journal of Pharmaceutics·Yu ZhengShixiang Hou
Sep 3, 2009·Journal of the American Chemical Society·Sheng-Tao YangYa-Ping Sun
Aug 6, 2010·Angewandte Chemie·Sheila N Baker, Gary A Baker
Dec 24, 2010·Biosensors & Bioelectronics·Zhuyuan WangYiping Cui
May 31, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nikhil Tyagi, Prahlad C Ghosh
Mar 19, 2013·Scientific Reports·Susanta Kumar BhuniaNikhil R Jana
Oct 15, 2013·Chemistry : a European Journal·Xing MaYanli Zhao
Apr 5, 2014·ACS Applied Materials & Interfaces·Susanta Kumar BhuniaNikhil R Jana
Jul 25, 2014·Chemical Communications : Chem Comm·Sukhendu NandiRaz Jelinek
Apr 29, 2015·The Analyst·Sukhendu NandiRaz Jelinek
Jan 1, 2010·Cancer Nanotechnology·Preethi SuriamoorthyWei Chen
Aug 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Weiqian KongZhenhui Kang
Mar 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hao LiZhenhui Kang
Sep 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hao LiZhenhui Kang
Sep 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Vadde RamuAmitava Das

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Citations

Sep 2, 2016·ACS Applied Materials & Interfaces·Susanta Kumar BhuniaRaz Jelinek
Dec 20, 2016·Analytical Chemistry·Sagarika BhattacharyaRaz Jelinek
Jun 28, 2018·Chemical Communications : Chem Comm·Ravit MalishevRaz Jelinek
Aug 5, 2017·Advanced Healthcare Materials·Nagappa L Teradal, Raz Jelinek
Jan 25, 2020·Advanced Healthcare Materials·Zhili PengRoger M Leblanc
Aug 21, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Albert GandiosoVicente Marchán
Dec 12, 2018·Frontiers in Chemistry·Naama Massad-IvanirEster Segal
Jan 22, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Ching-Yi Wu, Yu-Chie Chen
Mar 10, 2019·Mikrochimica Acta·Meghdad PirsahebMehrdad Payandeh
Sep 18, 2017·Analytical and Bioanalytical Chemistry·Daiana K DedaKoiti Araki
Mar 31, 2021·Journal of Fluorescence·N S VijilaSony George
May 10, 2021·Free Radical Biology & Medicine·Jean-François GoossensChristian Bailly
Aug 5, 2017·ACS Sensors·Sagarika BhattacharyaRaz Jelinek
May 1, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Elif S SevenRoger M Leblanc

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