Imaging Cell Death: Focus on Early Evaluation of Tumor Response to Therapy.

Bioconjugate Chemistry
Dongjian ZhangJian Zhang

Abstract

Cell death plays a prominent role in the treatment of cancer, because most anticancer therapies act by the induction of cell death including apoptosis, necrosis, and other pathways of cell death. Imaging cell death helps to identify treatment responders from nonresponders and thus enables patient-tailored therapy, which will increase the likelihood of treatment response and ultimately lead to improved patient survival. By taking advantage of molecular probes that specifically target the biomarkers/biochemical processes of cell death, cell death imaging can be successfully achieved. In recent years, with the increased understanding of the molecular mechanism of cell death, a variety of well-defined biomarkers/biochemical processes of cell death have been identified. By targeting these established cell death biomarkers/biochemical processes, a set of molecular imaging probes have been developed and evaluated for early monitoring treatment response in tumors. In this review, we mainly present the recent advances in identifying useful biomarkers/biochemical processes for both apoptosis and necrosis imaging and in developing molecular imaging probes targeting these biomarkers/biochemical processes, with a focus on their application ...Continue Reading

References

May 1, 1997·Experimental Cell Research·K EmotoM Umeda
Jul 1, 1997·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·B A KhawJ Narula
Mar 19, 2002·International Journal of Pharmaceutics·C Arteaga de MurphyE Molina-Trinidad
Jun 5, 2002·Annual Review of Biochemistry·Sandra L Wolin, Tommy Cedervall
Apr 4, 2003·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·D R OkadaR D Okada
May 27, 2003·Apoptosis : an International Journal on Programmed Cell Death·J D LyA Lawen
Aug 19, 2003·Molecular Imaging·Eyk A SchellenbergerLee Josephson
Aug 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jan H Ardenkjaer-LarsenKlaes Golman
Nov 25, 2003·Cancer Biotherapy & Radiopharmaceuticals·Xiaoxia WenChun Li
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marko RadicMarc Monestier
Jun 9, 2004·International Journal of Radiation Oncology, Biology, Physics·Rick L M HaasMarcel Verheij
Aug 3, 2004·Nature Reviews. Cancer·Hitoshi Okada, Tak W Mak
Sep 16, 2004·Bioconjugate Chemistry·Hyo-Il JungKevin M Brindle
Sep 16, 2004·Bioconjugate Chemistry·Eyk A SchellenbergerLee Josephson
Sep 29, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marina KartachovaMarcel Verheij
Aug 9, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David E SosnovikLee Josephson
Feb 2, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Yicheng NiGuy M Bormans
Feb 14, 2006·Science·Saquib A LakhaniRichard A Flavell
Jun 9, 2006·Journal of Biomolecular Screening·Catherine LaumonierRobert N Muller
Jul 20, 2006·Journal of the Royal Society, Interface·Paul J Cassidy, George K Radda
Dec 21, 2006·Journal of the American Chemical Society·W Matthew LeevyBradley D Smith
Apr 7, 2007·Nano Letters·André A NevesKevin M Brindle
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marina KartachovaRenato Alfredo Valdés Olmos
Sep 6, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Igal MadarJames J Frost
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fares Al-EjehMichael P Brown
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fares Al-EjehMichael P Brown
Nov 13, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Frank J P HoebersMarcel Verheij
Dec 21, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ravi K Amaravadi, Craig B Thompson
Jan 19, 2008·Nature Reviews. Cancer·Kevin Brindle
Mar 1, 2008·Apoptosis : an International Journal on Programmed Cell Death·Quan-Yong LuoRui-Sen Zhu
Mar 14, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Nathalie PerekFrancis Dubois
Mar 28, 2008·Journal of Cellular and Molecular Medicine·Narendra ThapaIn-San Kim
Jun 6, 2008·Bioorganic & Medicinal Chemistry Letters·Humphrey FongeAlfons Verbruggen
Jun 24, 2008·Biochimica Et Biophysica Acta·Andrei Marconescu, Philip E Thorpe
Jul 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ming ZhaoScott Bugenhagen
Aug 16, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ayelet ReshefIlan Ziv
Aug 30, 2008·Cancer Treatment Reviews·Elza C de Bruin, Jan Paul Medema
Oct 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jean Claude Reubi, Helmut R Maecke

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Citations

Jul 8, 2020·Cancers·Ana Beatriz VarandaRita Fior
Aug 13, 2020·Cancers·Segundo Francisco García-ArgüelloGraham Smith
Oct 14, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Libang ZhangJian Zhang
Nov 19, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Dongjian ZhangJian Zhang
Mar 14, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Min ChenJianghong Rao
Jul 8, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Vasilios LiapisAlexander H Staudacher

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