Abstract
Following stereotactic radiosurgery (SRS) for brain metastases, the median time range to develop adverse radiation effect (ARE) or radiation necrosis is 7-11 months. Similarly, the risk of local tumor recurrence following SRS is < 5% after 18 months. With improvements in systemic therapy, patients are living longer and are at risk for both late (defined as > 18 months after SRS) tumor recurrence and late ARE, which have not previously been well described. An IRB-approved, retrospective review identified patients treated with SRS who developed new MRI contrast enhancement > 18 months following SRS. ARE was defined as stabilization/shrinkage of the lesion over time or pathologic confirmation of necrosis, without tumor. Local failure (LF) was defined as continued enlargement of the lesion over time or pathologic confirmation of tumor. We identified 16 patients, with a median follow-up of 48.2 months and median overall survival of 73.0 months, who had 19 metastases with late imaging changes occurring a median of 32.9 months (range 18.5-63.2 months) after SRS. Following SRS, 12 lesions had late ARE at a median of 33.2 months and 7 lesions had late LF occurring a median of 23.6 months. As patients with cancer live longer and as SRS i...Continue Reading
References
May 10, 2000·International Journal of Radiation Oncology, Biology, Physics·E ShawN Farnan
Jun 19, 2001·International Journal of Cancer. Journal International Du Cancer·S T ChaoG Barnett
May 9, 2002·Journal of Neuro-oncology·Donald A RossDonna L Auer
Aug 24, 2007·Clinical Neurology and Neurosurgery·M CrockerR Selway
Oct 6, 2009·The Lancet Oncology·Eric L ChangChristina A Meyers
Jan 9, 2010·Journal of Neuro-oncology·Koichi MitsuyaMasahiro Endo
Nov 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin KocherRolf-Peter Mueller
May 18, 2011·Radiation Oncology·Giuseppe MinnitiRiccardo Maurizi Enrici
Jun 2, 2012·International Journal of Radiation Oncology, Biology, Physics·Clara Y H ChoiScott G Soltys
Jun 25, 2013·International Journal of Radiation Oncology, Biology, Physics·Samuel T ChaoJohn H Suh
Feb 4, 2014·Journal of Neuro-oncology·Giuseppe MinnitiLucio Trodella
Mar 14, 2014·The Lancet Oncology·Masaaki YamamotoKazuhiro Tsuchiya
Sep 4, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Francesco CiconeFrancesco Scopinaro
Dec 3, 2014·Neuro-oncology·Leor ZachYael Mardor
May 16, 2015·Journal of Neurosurgery·Penny K SneedMichael W McDermott
Jun 19, 2015·Oncotarget·Adam G JohnsonMichael D Chan
Jun 20, 2015·Journal of Neurosurgery·Samuel S ShinRobert M Friedlander
Jul 22, 2015·International Journal of Radiation Oncology, Biology, Physics·David B ShultzScott G Soltys
Aug 27, 2015·Journal of Neuro-oncology·Zachary A KohutekKathryn Beal
Oct 9, 2015·Yonsei Medical Journal·Yoon Jin ChaSe Hoon Kim
May 23, 2016·International Journal of Radiation Oncology, Biology, Physics·Giuseppe MinnitiVincenzo Esposito
Jul 28, 2016·JAMA : the Journal of the American Medical Association·Paul D BrownAnthony L Asher
Oct 16, 2016·International Journal of Radiation Oncology, Biology, Physics·Jacob A MillerAlireza M Mohammadi
Citations
May 8, 2018·Journal of Magnetic Resonance Imaging : JMRI·Stefanie C ThustMarion Smits
Oct 18, 2018·Acta neurochirurgica·Kira SeigerScott G Soltys
Sep 29, 2018·Neuro-oncology·Fabio Y MoraesDavid B Shultz
Apr 26, 2019·Topics in Magnetic Resonance Imaging : TMRI·Murat Alp OztekUpendra Parvathaneni
Apr 3, 2020·Journal of Neuro-oncology·Rami A El ShafieStefan Rieken
Sep 21, 2018·Frontiers in Oncology·Gokoulakrichenane LoganadaneAntonin Levy
Aug 9, 2020·Neuro-oncology Practice·Zaid A SiddiquiInga S Grills
Oct 30, 2020·Journal of Applied Clinical Medical Physics·Hisashi NakanoHidefumi Aoyama
Jan 5, 2021·Radiological Physics and Technology·Hisashi NakanoHiroyuki Ishikawa
Mar 31, 2021·The Journal of Molecular Diagnostics : JMD·Tejus A BaleMaria E Arcila
Sep 18, 2021·Current Opinion in Oncology·Lucia Nichelli, Stefano Casagranda
Oct 14, 2021·International Journal of Radiation Oncology, Biology, Physics·Roman O KowalchukJason P Sheehan