Imaging characteristics of BRAF-mutant non-small cell lung cancer by functional class

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Dexter P MendozaSubba Rao Digumarthy

Abstract

Mutations in the BRAF gene have emerged as a validated molecular target in the treatment of non-small cell lung cancer (NSCLC). These mutations can be classified into three functional classes based on their mechanisms of oncogenesis. The relationship between these functional classes and their imaging features has not been systematically investigated. The goal of this work is to determine if imaging features of the primary tumor and the pattern of metastasis correlate with the functional class of BRAF mutation. We reviewed pre-treatment computed tomography (CT) images of patients with BRAF-mutated NSCLC with known functional class. We assessed and recorded the features of the primary tumor and the patterns of lymphadenopathy and distant metastasis. Wilcoxon rank-sum test and Kruskal-Wallis test were performed to compare continuous characteristics, and Fisher's exact test was used to compare categorical features between groups. 105 patients with BRAF-mutant NSCLC had pre-treatment imaging available for review (n = 43 class I, n = 40 class II, and n = 22 class III). Approximately half of the primary tumors were considered masses (n = 54/105, 51%) and most were solid (n = 81/105, 77%). There were no statistically significant differ...Continue Reading

Citations

Sep 22, 2019·Cancers·Subba R DigumarthyLecia V Sequist
Aug 22, 2020·World Journal of Clinical Oncology·Dexter P MendozaSubba R Digumarthy
Dec 31, 2020·AJR. American Journal of Roentgenology·Dexter P MendozaSubba R Digumarthy
Nov 16, 2020·Clinical Lung Cancer·Sherief H GarranaSubba R Digumarthy

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