Imaging characteristics of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)

Bosnian Journal of Basic Medical Sciences
Dragan StojanovSasa Vujnovic

Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is an autosomal dominant vascular disorder. Diagnosis and follow-up in patients with CADASIL are based mainly on magnetic resonance imaging (MRI). MRI shows white matter hyperintensities (WMHs), lacunar infarcts and cerebral microbleeds (CMBs). WMHs lesions tend to be symmetrical and bilateral, distributed in the periventricular and deep white matter. The anterior temporal lobe and external capsules are predilection sites for WMHs, with higher specificity and sensitivity of anterior temporal lobe involvement compared to an external capsule involvement. Lacunar infarcts are presented by an imaging signal that has intensity of cerebrospinal fluid in all MRI sequences. They are localized within the semioval center, thalamus, basal ganglia and pons. CMBs are depicted as focal areas of signal loss on T2 images which increases in size on the T2*-weighted gradient echo planar images ("blooming effect").

Citations

Mar 12, 2017·Current Neurology and Neuroscience Reports·Anna Gryglas, Robert Smigiel
Nov 8, 2018·Der Radiologe·W Reith, A Haußmann
Sep 6, 2019·International Journal of Molecular Sciences·Vo Van GiauSang Yun Kim
May 18, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hussein AlgahtaniMuhammad Imran Naseer
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Jun 14, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yuan LiuQi Fang
Jun 19, 2019·Neuro-degenerative Diseases·Xiangyu ChenLamei Yuan

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