Imaging Diagnostic and Therapeutic Targets: Steroid Receptors in Breast Cancer.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Amy M FowlerFarrokh Dehdashti

Abstract

Estrogen receptor alpha (ERα) and progesterone receptor (PR) are important steroid hormone receptor biomarkers used to determine prognosis and to predict benefit from endocrine therapies for breast cancer patients. Receptor expression is routinely measured in biopsy specimens using immunohistochemistry, although such testing can be challenging, particularly in the setting of metastatic disease. ERα and PR can be quantitatively assayed noninvasively with PET. This approach provides the opportunity to assess receptor expression and function in real time, within the entire tumor, and across distant sites of metastatic disease. This article reviews the current evidence of ERα and PR PET imaging as predictive and early-response biomarkers for endocrine therapy.

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Citations

Feb 22, 2018·Journal of Nanobiotechnology·Kanchan ChauhanRafael Vazquez-Duhalt
Jul 1, 2020·Chemical Biology & Drug Design·Duo XuXianzhong Zhang
Jan 31, 2017·International Journal of Molecular Sciences·Simone U DalmMarion De Jong
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Feb 3, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Johannes Czernin, David Mankoff
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Dec 19, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Richard L WahlJohn Sunderland
Dec 24, 2018·Organic Letters·Jason C MixdorfHien M Nguyen

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