Imaging fast electrical activity in the brain with electrical impedance tomography

NeuroImage
Kirill Y AristovichD S Holder

Abstract

Imaging of neuronal depolarization in the brain is a major goal in neuroscience, but no technique currently exists that could image neural activity over milliseconds throughout the whole brain. Electrical impedance tomography (EIT) is an emerging medical imaging technique which can produce tomographic images of impedance changes with non-invasive surface electrodes. We report EIT imaging of impedance changes in rat somatosensory cerebral cortex with a resolution of 2ms and <200μm during evoked potentials using epicortical arrays with 30 electrodes. Images were validated with local field potential recordings and current source-sink density analysis. Our results demonstrate that EIT can image neural activity in a volume 7×5×2mm in somatosensory cerebral cortex with reduced invasiveness, greater resolution and imaging volume than other methods. Modeling indicates similar resolutions are feasible throughout the entire brain so this technique, uniquely, has the potential to image functional connectivity of cortical and subcortical structures.

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Citations

Sep 28, 2017·IEEE Transactions on Medical Imaging·Dong LiuJiangfeng Du
Feb 7, 2018·Physiological Measurement·T Dowrick, D Holder
Mar 30, 2017·Physiological Measurement·Mayo FaulknerDavid Holder
Mar 2, 2019·Physiological Measurement·James AveryDavid Holder
Mar 7, 2019·Physiological Measurement·Sana HannanDavid Holder
Oct 31, 2019·Electrophoresis·Marvin SchwarzIordania Constantinou
Jan 30, 2018·Frontiers in Neuroscience·Naomi A StaplesRylie A Green
Jun 27, 2019·Journal of Neural Engineering·Ilya TarotinDavid Holder
May 23, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W GamalP O Bagnaninchi
Oct 6, 2020·Physiological Measurement·Zeying WangYanqiu Wang
Aug 20, 2019·Journal of Electrical Bioimpedance·Mohammad Karimi MoridaniMandana Kia
Aug 18, 2020·Journal of Neuroscience Methods·Sana HannanDavid S Holder
Mar 3, 2018·NeuroImage·Anna Witkowska-WrobelDavid Holder

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