Imaging features of fibrolamellar hepatocellular carcinoma in gadoxetic acid-enhanced MRI

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
Viktoria PalmTim Frederik Weber

Abstract

Fibrolamellar hepatocellular carcinoma (FLC) is a rare malignancy occurring in young patients without cirrhosis. Objectives of our study were to analyze contrast material uptake in hepatobiliary phase imaging (HBP) in gadoxetic acid-enhanced liver MRI in patients with FLC and to characterize imaging features in sequence techniques other than HBP. In this retrospective study on histology-proven FLC, contrast material uptake in HBP was quantitatively assessed by calculating the corrected FLC enhancement index (CEI) using mean signal intensities of FLC and lumbar muscle on pre-contrast imaging and HBP, respectively. Moreover, enhancement patterns in dynamic contrast-enhanced MRI and relative signal intensities compared with background liver parenchyma were determined by two radiologists in consensus for HBP, diffusion-weighted imaging using high b-values (DWI), and T2 and T1 weighted pre-contrast imaging. In 6 of 13 patients with FLC gadoxetic acid-enhanced liver MRI was available. The CEI suggested presence of HBP contrast material uptake in all FLCs. A mean CEI of 1.35 indicated FLC signal increase of 35% in HBP compared with pre-contrast imaging. All FLCs were hypointense in HBP compared with background liver parenchyma. Three ...Continue Reading

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Citations

Dec 14, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Nobuhiro FujitaHiroshi Honda
Oct 18, 2019·Pediatric Radiology·Govind B ChavhanAbha A Gupta
Jun 17, 2020·World Journal of Gastroenterology : WJG·Jelena Djokic KovacIgor Dumic
Nov 19, 2020·JHEP Reports : Innovation in Hepatology·Elia GiganteJean-Charles Nault
Mar 7, 2021·Diagnostics·Bryony LucasIrina Pateva
Aug 22, 2021·European Journal of Medical Genetics·Henning WegeUNKNOWN rare liver tumors working group of the European Reference Network on Hepatological Diseases (ERN RARE-LIVER)
Jan 5, 2022·Liver International : Official Journal of the International Association for the Study of the Liver·Elvire DesjonqueresJean-Charles Nault

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