Imaging Features of Hypertrophic Olivary Degeneration

Journal of the Belgian Society of Radiology
Ruth Van EetveldeS Dekeyzer

Abstract

Hypertrophic olivary degeneration (HOD) is a unique form of transneuronal degeneration caused by a disruption of the dentato-rubro-olivary pathway, also known as the triangle of Guillain-Mollaret. The triangle of Guillain-Mollaret is involved in fine voluntary motor control and consists of both the inferior olivary nucleus and the red nucleus on one side and the contralateral dentate nucleus. Clinically, patients classically present with symptomatic palatal myoclonus. Typical magnetic resonance imaging findings include T2-hyperintensity and enlargement of the inferior olivary nucleus evolving over time to atrophy with residual T2-hyperintensity. In this article, we provide a case-based illustration of the anatomy of the Guillain-Mollaret-triangle and the typical imaging findings of hypertrophic olivary degeneration.

References

Jan 1, 1981·Acta Neuropathologica·N Goto, M Kaneko
Jan 25, 2008·Journal of Neuro-oncology·Serra AkarSantosh Kesari
Feb 28, 2009·The New England Journal of Medicine·C C Tchoyoson Lim, Su Ann Lim
Feb 15, 2012·Archives of Neurology·Michiko Kimura Bruno, G Frederick Wooten
Feb 2, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Eberhard SiebertMartin Herbst
Mar 15, 2013·Acta Radiologica·Yuki ShinoharaToshihide Ogawa
Apr 11, 2014·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Carrie M CarrChristopher P Wood
Jun 16, 2015·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Chris N GuChristopher P Wood

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