Imaging Features of Neurofibromatosis Type 1 in the Abdomen and Pelvis.

AJR. American Journal of Roentgenology
Maria ZulfiqarCary Lynn Siegel

Abstract

OBJECTIVE. Loss of the neurofibromatosis type 1 (NF1) tumor suppressor protein causes uninhibited activation of the RAS oncogene, which leads to tumorigenesis in patients with NF1. This case-based review discusses imaging manifestations of NF1 in the abdomen and pelvis, highlighting key genetic associations and management to elucidate features different from the general population. CONCLUSION. The spectrum of pathologic findings includes gastrointestinal tumors such as gastrointestinal stromal tumors, genitourinary lesions including urogenital neurofibromas, vascular entities such as renal artery stenosis, and less common associations like lymphoma.

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Jun 26, 2021·Der Radiologe·K GlutigD M Renz
Jul 24, 2021·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Maria ZulfiqarCary Lynn Siegel

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