Imaging findings in children with proliferative disorders following multivisceral transplantation

Pediatric Radiology
Anastasia L HryhorczukEdward Y Lee

Abstract

Multivisceral transplantation represents an important treatment option for children with intestinal failure. The attendant immunosuppression can lead to a spectrum of cellular proliferations including benign and malignant smooth muscle tumors and lymphoproliferative disorders, many related to cellular dysregulation from Epstein-Barr virus infection. The purpose of this study is to investigate the rates of post-transplantation proliferative disorders among children with multivisceral transplantation and to characterize the imaging and pathological features of these disorders. We identified all consecutive children who underwent multivisceral transplant from August 2004 to October 2011 with at least 27 months of clinical and imaging follow-up. We reviewed medical records to determine the underlying causes of the multivisceral transplant, age at transplantation, onset of neoplasm development, and outcome. Two pediatric radiologists reviewed all imaging studies independently and diagnosis of disease was made by consensus interpretation. Pathological specimens were reviewed for histopathological findings of post-transplantation neoplasm in this pediatric patient population. The study population consisted of 14 consecutive pediatric ...Continue Reading

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Citations

Feb 21, 2016·Radiologic Clinics of North America·A Luana StanescuGrace S Phillips
Jun 12, 2018·Clinical Transplantation·Laura J WozniakDouglas G Farmer
Feb 20, 2020·Current Opinion in Organ Transplantation·Robert S VenickJordan Whatley

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