Imaging genetics and psychiatric disorders

Current Molecular Medicine
R HashimotoM Takeda

Abstract

Imaging genetics is an integrated research method that uses neuroimaging and genetics to assess the impact of genetic variation on brain function and structure. Imaging genetics is both a tool for the discovery of risk genes for psychiatric disorders and a strategy for characterizing the neural systems affected by risk gene variants to elucidate quantitative and mechanistic aspects of brain function implicated in psychiatric disease. Early studies of imaging genetics included association analyses between brain morphology and single nucleotide polymorphisms whose function is well known, such as catechol-Omethyltransferase (COMT) and brain-derived neurotrophic factor (BDNF). GWAS of psychiatric disorders have identified genes with unknown functions, such as ZNF804A, and imaging genetics has been used to investigate clues of the biological function of these genes. The difficulty in replicating the findings of studies with small sample sizes has motivated the creation of largescale collaborative consortiums, such as ENIGMA, CHARGE and IMAGEN, to collect thousands of images. In a genome-wide association study, the ENIGMA consortium successfully identified common variants in the genome associated with hippocampal volume at 12q24, and...Continue Reading

Citations

Feb 26, 2016·Cellular and Molecular Life Sciences : CMLS·Silvia SacchiLoredano Pollegioni
Dec 13, 2017·The European Journal of Neuroscience·Kevin J Mitchell
Jul 30, 2019·Frontiers in Psychiatry·Wenhao JiangJessica A Turner
Jan 8, 2019·F1000Research·Roderic Guigo, Michiel de Hoon
Apr 21, 2020·Journal of Alzheimer's Disease : JAD·Bo-Hyun KimUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 20, 2020·Bioinformatics·Canhong WenUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Aug 1, 2020·NeuroImage·Andrea PalkDan J Stein
Jul 4, 2020·Bioinformatics·Canhong WenUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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Software Mentioned

ENIGMA
FreeSurfer
CHARGE
IMAGEN

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