Abstract
Imaging genetics is an integrated research method that uses neuroimaging and genetics to assess the impact of genetic variation on brain function and structure. Imaging genetics is both a tool for the discovery of risk genes for psychiatric disorders and a strategy for characterizing the neural systems affected by risk gene variants to elucidate quantitative and mechanistic aspects of brain function implicated in psychiatric disease. Early studies of imaging genetics included association analyses between brain morphology and single nucleotide polymorphisms whose function is well known, such as catechol-Omethyltransferase (COMT) and brain-derived neurotrophic factor (BDNF). GWAS of psychiatric disorders have identified genes with unknown functions, such as ZNF804A, and imaging genetics has been used to investigate clues of the biological function of these genes. The difficulty in replicating the findings of studies with small sample sizes has motivated the creation of largescale collaborative consortiums, such as ENIGMA, CHARGE and IMAGEN, to collect thousands of images. In a genome-wide association study, the ENIGMA consortium successfully identified common variants in the genome associated with hippocampal volume at 12q24, and...Continue Reading
Citations
Feb 26, 2016·Cellular and Molecular Life Sciences : CMLS·Silvia SacchiLoredano Pollegioni
May 21, 2016·Frontiers in Psychiatry·Cyrus S H HoRoger C M Ho
Mar 23, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marc Fakhoury
Nov 3, 2017·NPJ Schizophrenia·Julia H HarariCelso Arango
Dec 12, 2017·Translational Psychiatry·Annie LeeAnqi Qiu
Jan 10, 2018·Frontiers in Psychiatry·Kazutaka OhiRyota Hashimoto
Dec 13, 2017·The European Journal of Neuroscience·Kevin J Mitchell
Feb 12, 2019·PloS One·Ji Hye WonHyunjin Park
May 12, 2018·Brain Imaging and Behavior·Zalina DezhinaDanai Dima
Mar 25, 2016·PloS One·William C ReidDima A Hammoud
Jun 6, 2020·Human Brain Mapping·Daisuke KoshiyamaRyota Hashimoto
Aug 22, 2020·Neuroinformatics·Lu ZhaoArthur W Toga
Jul 30, 2019·Frontiers in Psychiatry·Wenhao JiangJessica A Turner
Jan 8, 2019·F1000Research·Roderic Guigo, Michiel de Hoon
May 31, 2019·Parkinson's Disease·Yan ZhiKezhong Zhang
Apr 21, 2020·Journal of Alzheimer's Disease : JAD·Bo-Hyun KimUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 20, 2020·Bioinformatics·Canhong WenUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Aug 1, 2020·NeuroImage·Andrea PalkDan J Stein
Jul 4, 2020·Bioinformatics·Canhong WenUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Apr 21, 2021·Behavioural Brain Research·Zhuoliang HouYonggui Yuan
Apr 1, 2021·ELife·Bo-Yong ParkBoris C Bernhardt