Imaging genetics of structural brain connectivity and neural integrity markers.

NeuroImage
Stefano Marenco, Eugenia Radulescu

Abstract

We review studies that have used diffusion imaging (DI) and magnetic resonance spectroscopy (MRS) to investigate genetic associations. A brief description of the measures obtainable with these methods and of some methodological and interpretability limitations is given. The usefulness of DI and MRS in defining intermediate phenotypes and in demonstrating the effects of common genetic variants known to increase risk for psychiatric manifestations on anatomical and metabolic phenotypes is reviewed. The main focus is on schizophrenia where the greatest amount of data has been collected. Moreover, we present an example coming from a different approach, where the genetic alteration is known (the deletion that causes Williams syndrome) and the DI phenotype can shed new light on the function of genes affected by the mutation. We conclude that, although these are still early days of this type of research and many findings remain controversial, both techniques can significantly contribute to the understanding of genetic effects in the brain and the pathophysiology of psychiatric disorders.

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D L RothmanR G Shulman
Jan 1, 1992·Clinical Neuropharmacology·D R WeinbergerE F Torrey
Jun 1, 1996·Journal of Magnetic Resonance. Series B·P J Basser, C Pierpaoli
Jan 1, 1996·Schizophrenia Bulletin·J A StanleyR T Thompson
Dec 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C Pierpaoli, P J Basser
Feb 14, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·M S KeshavanJ A Sweeney
Apr 29, 1998·Schizophrenia Research·E T BullmoreR M Murray
Oct 23, 1998·Archives of General Psychiatry·C M MazzantiD Goldman
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·J ShenD L Rothman
Oct 9, 1999·Psychiatry Research·A PfefferbaumK O Lim
May 18, 2000·Human Molecular Genetics·J K MillarD J Porteous
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
Oct 25, 2001·Proceedings of the National Academy of Sciences of the United States of America·B CzéhE Fuchs
Nov 3, 2001·The American Journal of Psychiatry·A Meyer-LindenbergK F Berman
Sep 28, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David S TuchVan J Wedeen
Oct 29, 2002·Annals of Neurology·Ognen A C PetroffDennis D Spencer
Mar 22, 2003·Experimental Cell Research·Douglas L Falls
Mar 27, 2003·Journal of Neural Transmission·M P LaaksoH Soininen
Dec 9, 2003·Neuron·David S TuchVan J Wedeen
Dec 18, 2003·NMR in Biomedicine·Robin A de GraafDouglas L Rothman
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael F EganDaniel R Weinberger

❮ Previous
Next ❯

Citations

Apr 19, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Omid KohannimPaul M Thompson
Nov 22, 2011·NeuroImage·Heike TostAndreas Meyer-Lindenberg
Jan 18, 2011·Psychiatry Research·Antonio CerasaGianfranco Spalletta
Oct 26, 2013·Neuroscience and Biobehavioral Reviews·Tianzi JiangMing Song
Jan 24, 2015·Neuroscience and Biobehavioral Reviews·Giulio PergolaGiuseppe Blasi
Mar 26, 2013·Schizophrenia Research·Patrick A E DomenUNKNOWN for G.R.O.U.P
Mar 13, 2012·Schizophrenia Research·Kristi ClarkRochelle Caplan
Sep 8, 2010·NeuroImage·Lukas Pezawas, Andreas Meyer-Lindenberg
Jun 3, 2016·Frontiers in Human Neuroscience·Sayed H TadayonAbdolhossein Abbassian
Jul 6, 2019·The Canadian Journal of Statistics = Revue Canadienne De Statistique·Farouk S NathooHongtu Zhu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Related Papers

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Andreas KonradGeorg Winterer
Journal of Psychiatric Research
Marek KubickiMartha E Shenton
© 2022 Meta ULC. All rights reserved