Imaging genetics paradigms in depression research: Systematic review and meta-analysis

Progress in Neuro-psychopharmacology & Biological Psychiatry
Lícia P PereiraAndré F Carvalho

Abstract

Imaging genetics studies involving participants with major depressive disorder (MDD) have expanded. Nevertheless, findings have been inconsistent. Thus, we conducted a systematic review and meta-analysis of imaging genetics studies that enrolled MDD participants across major databases through June 30th, 2017. Sixty-five studies met eligibility criteria (N = 4034 MDD participants and 3293 controls), and there was substantial between-study variability in the methodological quality of included studies. However, few replicated findings emerged from this literature with only 22 studies providing data for meta-analyses (882 participants with MDD and 616 controls). Total hippocampal volumes did not significantly vary in MDD participants or controls carrying either the BDNF Val66Met 'Met' (386 participants with MDD and 376 controls) or the 5-HTTLPR short 'S' (310 participants with MDD and 230 controls) risk alleles compared to non-carriers. Heterogeneity across studies was explored through meta-regression and subgroup analyses. Gender distribution, the use of medications, segmentation methods used to measure the hippocampus, and age emerged as potential sources of heterogeneity across studies that assessed the association of 5-HTTLPR s...Continue Reading

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Citations

Aug 12, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amanda M Buch, Conor Liston
Aug 8, 2021·International Journal of Molecular Sciences·Eugene LinHsien-Yuan Lane
Oct 26, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Eugene LinHsien-Yuan Lane

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