Imaging Glaucoma

Annual Review of Vision Science
Donald C Hood

Abstract

Optical coherence tomography (OCT) is changing the way glaucoma is studied and diagnosed. Glaucoma damages retinal ganglion cell (RGC) axons at the optic disc, and the resulting retrograde degeneration destroys the RGC bodies. OCT allows for a noninvasive measurement of both retinal nerve fiber (RNF) and RGC layer thickness. In this article, OCT techniques are described for studying the thinning of these layers due to glaucoma. We have learned that there is more damage to the macula (central ±8 deg) than previously thought, and a simple anatomical model provides an explanation for this finding. Further, OCT technology has led to improved understanding of the relationship between RGC and RNF layer loss and behavioral data. Finally, another imaging technique, adaptive optics, has allowed a better visualization and understanding of details that are often difficult or impossible to see with current OCT technology.

References

Feb 1, 1992·Ophthalmology·R VarmaI U Scott
Nov 22, 1991·Science·D HuangC A Puliafito
Oct 1, 1990·The Journal of Comparative Neurology·C A Curcio, K A Allen
May 15, 1989·American Journal of Ophthalmology·H A QuigleyW R Green
Jan 1, 1989·International Ophthalmology·J WeberH Ulrich
Mar 1, 1984·Archives of Ophthalmology·J L Anctil, D R Anderson
Feb 20, 1999·Survey of Ophthalmology·J B JonasS Panda-Jonas
Oct 3, 2000·Ophthalmology·D F Garway-HeathR A Hitchings
Dec 10, 2002·Archives of Ophthalmology·Donald C HoodPhamornsak Thienprasiddhi
Apr 3, 2003·Journal of Glaucoma·Patricia NelsonColm O'Brien
Jan 28, 2004·Investigative Ophthalmology & Visual Science·William H SwansonFei Pan
Nov 22, 2005·Optometry : Journal of the American Optometric Association·Murray FingeretRobert N Weinreb
Jul 15, 2006·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Fei PanMitchell W Dul
Feb 16, 2007·Current Opinion in Ophthalmology·Remo Susanna, Roberto M Vessani
Apr 13, 2007·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Donald C Hood
Sep 25, 2007·Progress in Retinal and Eye Research·Donald C Hood, Randy H Kardon
Oct 16, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ronald S Harwerth, Joe L Wheat
Feb 28, 2008·Current Opinion in Ophthalmology·Robert Chang, Donald L Budenz
Jun 10, 2008·Investigative Ophthalmology & Visual Science·Ronald S HarwerthNalini V Rangaswamy
Dec 17, 2008·Survey of Ophthalmology·Pooja SharmaJoel S Schuman
Jun 12, 2010·Investigative Ophthalmology & Visual Science·Ulrich SchieferJens Paetzold
Oct 1, 2010·Investigative Ophthalmology & Visual Science·Donald C HoodRobert Ritch
Nov 16, 2010·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Donald C HoodMin Wang
Dec 15, 2010·Archives of Ophthalmology·Jesse RichmanGeorge L Spaeth
Mar 23, 2011·Investigative Ophthalmology & Visual Science·Christine A CurcioRichard F Spaide
Jun 24, 2011·Biomedical Optics Express·Alfredo Dubra, Yusufu Sulai
Jul 13, 2011·Archives of Ophthalmology·Harsha L RaoFelipe A Medeiros
Dec 14, 2011·Archives of Ophthalmology·Ali S RazaDonald C Hood
Feb 22, 2012·Clinical & Experimental Ophthalmology·Rizwan MalikDavid F Garway-Heath
Sep 22, 2012·Progress in Retinal and Eye Research·Donald C HoodRobert Ritch
Nov 15, 2012·Ophthalmology·Daniel SuRobert Ritch
Jan 29, 2013·American Journal of Ophthalmology·Kohei TakayamaNagahisa Yoshimura
Apr 30, 2013·Translational Vision Science & Technology·Donald C HoodRobert Ritch
Dec 29, 2013·Investigative Ophthalmology & Visual Science·Donald C HoodRobert Ritch

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Citations

Aug 3, 2021·Ophthalmology. Glaucoma·Huiyuan HouRobert N Weinreb

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Methods Mentioned

BETA
imaging technique

Software Mentioned

AOSLO
fdOCT

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