Imaging mass spectrometry for natural products discovery: a review of ionization methods.

Natural Product Reports
Joseph E SprakerLaura M Sanchez

Abstract

Covering: 2009-2019 Over the last decade, methods in imaging mass spectrometry (IMS) have progressively improved and diversified toward a variety of applications in natural products research. Because IMS allows for the spatial mapping of the production and distribution of biologically active molecules in situ, it facilitates phenotype and organelle driven discovery efforts. As practitioners of IMS for natural products discovery, we find one of the most important aspects of these experiments is the sample preparation and compatibility with different ionization sources that are available to a given researcher. As such, we have focused this mini review to cover types of ionization sources that have been used in natural products discovery applications and provided concrete examples of use for natural products discovery while discussing the advantages and limitations of each method. We aim for this article to serve as a resource to guide the broader natural product community interested in IMS toward the application/method that would best serve their natural product discovery needs given the sample and analyte(s) of interest. This mini review has been limited to applications using natural products and thus is not exhaustive of all po...Continue Reading

References

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Citations

Dec 12, 2019·Journal of Natural Products·Sonja L KnowlesNicholas H Oberlies
May 13, 2021·Metabolomics : Official Journal of the Metabolomic Society·Biswapriya B Misra
Jun 1, 2021·Annual Review of Biomedical Data Science·Theodore Alexandrov
Jul 11, 2021·Journal of Separation Science·Wenya HuHonggang Nie
Aug 14, 2020·Journal of Proteome Research·Fernando Tobias, Amanda B Hummon
Apr 25, 2020·Journal of the American Society for Mass Spectrometry·Gordon T LuuLaura M Sanchez
Oct 7, 2021·Natural Product Reports·Scott A JarmuschAlan K Jarmusch

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Methods Mentioned

BETA
imaging techniques
electron microscopy
atomic force microscopy
fluorescence microscopy
X-ray

Software Mentioned

IR
LAESI
DESI
MALDESI
DART
nanoDESI
imzML
LAESI IMS
IMS
LESA

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