Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease

Biochimica Et Biophysica Acta. Biomembranes
E González de San RománR Rodríguez-Puertas

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting millions of patients worldwide. Previous studies have demonstrated alterations in the lipid composition of lipid extracts from plasma and brain samples of AD patients. However, there is no consensus regarding the qualitative and quantitative changes of lipids in brains from AD patients. In addition, the recent developments in imaging mass spectrometry methods are leading to a new stage in the in situ analysis of lipid species in brain tissue slices from human postmortem samples. The present study uses the matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS), permitting the direct anatomical analysis of lipids in postmortem brain sections from AD patients, which are compared with the intensity of the lipid signal in samples from matched subjects with no neurological diseases. The frontal cortex samples from AD patients were classified in three groups based on Braak's histochemical criteria, ranging from non-cognitively impaired patients to those severely affected. The main results indicate a depletion of different sulfatide lipid species from the earliest stages of the disease in both white and gray matter areas of the fron...Continue Reading

Citations

Feb 27, 2017·Biochimica Et Biophysica Acta. Biomembranes·J Martínez-GardeazabalR Rodríguez-Puertas
Jun 5, 2018·Bioanalysis·Cosima D CalvanoTommaso Ri Cataldi
May 31, 2018·Critical Reviews in Food Science and Nutrition·Sunil K RaviBruno Vincent
May 29, 2018·Journal of Neurochemistry·Mandana HunterMaurice A Curtis
Feb 9, 2019·Current Protocols in Molecular Biology·Matthew B O'RourkeMatthew P Padula
Feb 13, 2020·International Journal of Molecular Sciences·Siddhartha BanerjeeYuri L Lyubchenko
Oct 15, 2019·Frontiers in Molecular Neuroscience·Estíbaliz González de San RománRafael Rodríguez Puertas
Oct 14, 2020·Journal of Neurochemistry·Martina Blank, Carsten Hopf
Aug 20, 2019·Journal of Molecular Biology·Joan Bestard-EscalasGwendolyn Barceló-Coblijn
Jan 16, 2021·Frontiers in Neuroendocrinology·Daniel Báez CastellanosJanneth González
Jun 23, 2020·Neurobiology of Disease·Emma Jones, Simon Mead
May 27, 2021·ACS Chemical Neuroscience·Alberto Llorente-OvejeroRafael Rodríguez-Puertas
Jun 9, 2021·Expert Review of Proteomics·Mariona JovéReinald Pamplona
Jun 8, 2021·Journal of Alzheimer's Disease : JAD·Johan SvenssonAnders Wallin
Jan 24, 2020·Journal of the American Society for Mass Spectrometry·Aaron HarrisShawn N Whitehead
Nov 22, 2019·Analytical Chemistry·Roberto FernándezJosé A Fernández
Aug 29, 2021·Metabolomics : Official Journal of the Metabolomic Society·Pierluigi RevegliaGaetano Corso
Oct 6, 2021·Scientific Reports·Gianluca SighinolfiBoutayna Rhourri-Frih

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