Imaging Mass Spectrometry Reveals a Unique Distribution of Triglycerides in the Abdominal Aortic Aneurysmal Wall

Journal of Vascular Research
Hiroki TanakaNaoki Unno

Abstract

The pathophysiology underlying abdominal aortic aneurysms (AAAs) remains unknown. In this study, we applied imaging mass spectrometry (IMS) to analyze the pathophysiology of the aneurysmal wall. Comparisons were performed between the tissue samples from the neck and the sac of the AAA, at a single time point, in 30 patients who underwent elective surgery of their AAAs. The localization of each lipid molecule in the aortic wall was assessed by IMS. Histopathological examination and IMS revealed a characteristic distribution of triglycerides (TGs) specifically in the aneurismal adventitia of the sac. This characteristic TG distribution was derived from an ectopic appearance of adipocytes in the adventitia. Furthermore, ectopic adipocyte accumulation in the aortic wall leads to the loss of the collagen fiber network subsequent to the wall rupture. The underlying mechanism of adipocyte accumulation involves the presence of adipose-derived stem cells (ADSCs) in the aneurismal adventitia and the expression of peroxisome proliferator-activated receptor gamma 2, a master regulator of adipocyte differentiation by some ADSCs. This study reveals new, previously overlooked aspects of AAA pathology.

Citations

Aug 9, 2016·Scientific Reports·Hirona KugoTatsuya Moriyama
Mar 16, 2017·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Lara T MeitalFraser D Russell
Mar 14, 2017·Journal of Proteome Research·Mahim I QureshiAlun H Davies
Jul 7, 2017·Journal of Vascular Research·Hiroki TanakaNaoki Unno
Feb 9, 2019·Current Protocols in Molecular Biology·Matthew B O'RourkeMatthew P Padula
May 1, 2019·Analytical and Bioanalytical Chemistry·Christina MeisenbichlerThomas Müller
Dec 7, 2018·Journal of Oleo Science·Hirona KugoNobuhiro Zaima
Aug 18, 2018·Annals of Vascular Diseases·Hirona KugoNobuhiro Zaima
Apr 14, 2019·Analytical and Bioanalytical Chemistry·Stephanie T P MezgerRon M A Heeren

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