PMID: 11604592Oct 18, 2001Paper

Imaging modalities in central nervous system systemic lupus erythematosus

Current Opinion in Rheumatology
T W J HuizingaM A van Buchem

Abstract

Within the past few years, a clearly defined case definition system for central nervous system systemic lupus erythematosus (CNS-SLE) has been established. This has allowed cross-study comparisons of patients fulfilling the specific case definitions. New imaging techniques used on the subgroup of CNS-SLE patients that did not have any evidence for infarctions suggest that in these patients symptoms are associated with a diffuse process in the brain. Most likely this process leads to axonal damage and demyelination, ultimately leading to cerebral atrophy. With respect to the diagnostic work-up of SLE patients with neuropsychiatric symptoms, it has become clear that cranial magnetic resonance imaging is the technique of choice. Preliminary studies using quantitative magnetic resonance imaging techniques suggest that patients with neuropsychiatric symptoms caused by active CNS-SLE can be differentiated from patients with the same symptoms caused by residual disease.

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Citations

Dec 18, 2007·Clinical Reviews in Allergy & Immunology·Simone AppenzellerAnn E Clarke
Apr 8, 2014·Autoimmunity Reviews·Enrico Maria ZardiAntonella Afeltra
Feb 16, 2013·Brain Research·Sean FoxleyJessy John Alexander
Feb 5, 2010·Arthritis and Rheumatism·Georgia RamantaniMin Ae Lee-Kirsch
May 13, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Isabel Junie Hildebrandt, Sanjiv Sam Gambhir
Jun 24, 2005·Journal of Neuroimmunology·Michelle M SidorJoseph Macri
Nov 7, 2002·Critical Care Clinics·Rishi RajHerbert P Wiedemann
May 10, 2006·Advances in Immunology·Betty DiamondBruce T Volpe
Oct 1, 2004·Arthritis and Rheumatism·S C A SteensM A Van Buchem
Aug 31, 2006·Journal of Magnetic Resonance Imaging : JMRI·Bart J EmmerMark A van Buchem
Jan 29, 2008·Journal of Magnetic Resonance Imaging : JMRI·Danieli Castro Oliveira de AndradeAntônio Carlos Maia
Sep 6, 2005·Arthritis and Rheumatism·Simone AppenzellerFernando Cendes
Mar 21, 2007·Magnetic Resonance Imaging·Lijuan ZhangAziz M Uluğ

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