Imaging Modalities to Assess Oxygen Status in Glioblastoma

Frontiers in Medicine
Aurélien Corroyer-DulmontSamuel Valable

Abstract

Hypoxia, the result of an inadequacy between a disorganized and functionally impaired vasculature and the metabolic demand of tumor cells, is a feature of glioblastoma. Hypoxia promotes the aggressiveness of these tumors and, equally, negatively correlates with a decrease in outcome. Tools to characterize oxygen status are essential for the therapeutic management of patients with glioblastoma (i) to refine prognosis, (ii) to adapt the treatment regimen, and (iii) to assess the therapeutic efficacy. While methods that are focal and invasive in nature are of limited use, non-invasive imaging technologies have been developed. Each of these technologies is characterized by its singular advantages and limitations in terms of oxygenation status in glioblastoma. The aim of this short review is, first, to focus on the interest to characterize hypoxia for a better therapeutic management of patients and, second, to discuss recent and pertinent approaches for the assessment of oxygenation/hypoxia and their direct implication for patient care.

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Citations

Aug 9, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ararat ChakhoyanSamuel Valable
Aug 2, 2019·Journal of Medical Imaging and Radiation Oncology·Tristan B ShawBenjamin Chua
May 20, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Philip V LittleStaffan Holmin
Dec 21, 2019·EJNMMI Research·Elodie A PérèsSamuel Valable
Dec 28, 2019·International Journal of Molecular Sciences·Juliette ThariatFrançois Chevalier
Mar 21, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Lien BekaertJean-Sébastien Guillamo

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Methods Mentioned

BETA
biopsy
electron paramagnetic resonance
surgical resection

Software Mentioned

FMISO
qBOLD

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