Imaging Modalities to Identity Inflammation in an Atherosclerotic Plaque

Radiology Research and Practice
Sunny GoelOn Chen

Abstract

Atherosclerosis is a chronic, progressive, multifocal arterial wall disease caused by local and systemic inflammation responsible for major cardiovascular complications such as myocardial infarction and stroke. With the recent understanding that vulnerable plaque erosion and rupture, with subsequent thrombosis, rather than luminal stenosis, is the underlying cause of acute ischemic events, there has been a shift of focus to understand the mechanisms that make an atherosclerotic plaque unstable or vulnerable to rupture. The presence of inflammation in the atherosclerotic plaque has been considered as one of the initial events which convert a stable plaque into an unstable and vulnerable plaque. This paper systemically reviews the noninvasive and invasive imaging modalities that are currently available to detect this inflammatory process, at least in the intermediate stages, and discusses the ongoing studies that will help us to better understand and identify it at the molecular level.

References

Jan 1, 1990·Ultrasound in Medicine & Biology·B WidderJ Vollmar
Feb 1, 1980·AJR. American Journal of Roentgenology·A H BarrettN L Sadowsky
Aug 1, 1995·Circulation·E FalkV Fuster
Mar 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·J F ToussaintH L Kantor
May 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R VirmaniS M Schwartz
Sep 23, 2000·Nature·A J Lusis
Aug 18, 2001·Circulation Research·Z A Fayad, V Fuster
Oct 6, 2001·The International Journal of Cardiovascular Imaging·Z A Fayad
Feb 19, 2002·Journal of the American College of Cardiology·Ik-Kyung JangGuillermo J Tearney
Apr 17, 2002·Journal of the American College of Cardiology·Jing WangWard Casscells
Mar 26, 2003·Journal of Magnetic Resonance Imaging : JMRI·Lee M MitsumoriChun Yuan
Jul 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Steven B Feinstein
Sep 1, 2004·Journal of the American College of Cardiology·Briain D MacNeillGuillermo J Tearney
Jan 18, 2005·Circulation Research·Kimberly A KellyRalph Weissleder
Dec 6, 2005·Journal of the American College of Cardiology·Gastón A Rodriguez-GranilloPatrick W Serruys
Dec 20, 2005·The International Journal of Cardiovascular Imaging·Gastón A Rodriguez-GranilloPatrick W Serruys
Apr 22, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Rikin A TrivediJonathan H Gillard
Apr 25, 2006·Journal of the American College of Cardiology·Renu VirmaniFrank D Kolodgie
May 16, 2006·European Radiology·Sebastian LeschkaHatem Alkadhi
Sep 26, 2006·American Heart Journal·Teruyoshi KumeKiyoshi Yoshida
Nov 7, 2006·Journal of the American College of Cardiology·Nobuhiro TaharaTsutomu Imaizumi
Jul 20, 2007·European Radiology·Jens BremerichPeter Reimer

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Citations

Sep 19, 2016·Advanced Drug Delivery Reviews·Carolin ReimannMarcus R Makowski
Mar 7, 2017·Vascular Pharmacology·J R NelsonM Budoff
May 31, 2018·Clinics·Jéssica Cavalcante Dos SantosVivian Nogueira Silbiger
Sep 27, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jonathan VigneUNKNOWN Cardiovascular study group of the European Society of Molecular Imaging

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Methods Mentioned

BETA
imaging techniques
imaging technique
imaging
infrared spectroscopy
Infrared

Software Mentioned

VHIVUS
VH
IVUS

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Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.