Imaging molecular pathways: reporter genes.

Radiation Research
John BroganChuan-Yuan Li

Abstract

Molecular imaging is a rapidly advancing field that allows cancer biologists to look deeper into the complex inner workings of tumor cells, or whole tumors, in a non-invasive manner. In this review, we will summarize some recent advances that enable investigators to study various important biological processes in tumors in vivo. We will discuss novel imaging approaches that allow investigators to visualize and quantify molecular pathways, such as receptor tyrosine kinase activation, hypoxia signal transduction, apoptosis, and DNA double-strand breaks. Select examples of these applications will be discussed. Because of the limited scope of this review, we will only focus on natural reporters, such as bioluminescence and fluorescent proteins.

References

Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G L SemenzaS E Antonarakis
Nov 15, 1988·Analytical Biochemistry·S J Gould, S Subramani
Feb 11, 1994·Science·M ChalfieD C Prasher
Oct 24, 1997·Photochemistry and Photobiology·C H ContagD A Benaron
Oct 3, 1999·Nature Biotechnology·M V MatzS A Lukyanov
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·T J SweeneyC H Contag
Apr 3, 2002·Trends in Molecular Medicine·Gregg L Semenza
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert E CampbellRoger Y Tsien
Nov 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·R PaulmuruganS S Gambhir
Dec 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·Bharathi LaxmanAlnawaz Rehemtulla
Feb 28, 2003·Nature·Michal GoldbergStephen P Jackson
Feb 28, 2003·Nature·Grant S StewartStephen J Elledge
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
Jun 1, 1962·Journal of Cellular and Comparative Physiology·O SHIMOMURAY SAIGA
Dec 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yu-An CaoChristopher H Contag
Jan 18, 2005·Cancer Cell·Shimon Gross, David Piwnica-Worms
Nov 5, 2005·Trends in Biotechnology·Dmitriy M ChudakovKonstantin A Lukyanov
Nov 22, 2005·Nature Methods·Nathan C ShanerRoger Y Tsien
May 26, 2006·Nature Reviews. Immunology·Robert S Negrin, Christopher H Contag
Jan 27, 2007·Current Opinion in Biotechnology·Tarik F MassoudSanjiv S Gambhir
Apr 17, 2007·Molecular Cell·Fang LiChuan-Yuan Li
Apr 28, 2007·Annual Review of Biomedical Engineering·Victor VillalobosDavid Piwnica-Worms
Aug 19, 2007·Nature Medicine·Limin ZhangAlnawaz Rehemtulla
Oct 12, 2010·International Journal of Radiation Oncology, Biology, Physics·Frank WolfChuan-Yuan Li
Jul 16, 2011·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Frank WolfChuan-Yuan Li
Jul 19, 2011·Nature Biotechnology·Grigory S FilonovVladislav V Verkhusha
Mar 1, 2012·Radiation Research·Gregory M PalmerMark W Dewhirst

❮ Previous
Next ❯

Citations

Mar 29, 2013·Nature Reviews. Cancer·Michael HölzelThomas Tüting
Feb 26, 2014·Journal of Gastroenterology·Sarah Schwitalla
Oct 12, 2012·Cellular and Molecular Life Sciences : CMLS·Erik H J G AarntzenI Jolanda M de Vries
Sep 26, 2014·Nanomedicine·C D Shaw, K C Carter
Dec 24, 2015·Neoplasia : an International Journal for Oncology Research·Pierre DanhierZaver M Bhujwalla
Feb 13, 2013·Annals of the New York Academy of Sciences·Carlo ContoreggiGeorge Chrousos
May 8, 2014·Biochimica Et Biophysica Acta·Yulia ModestovaNatalia N Ugarova
Jan 13, 2015·Nuclear Medicine and Biology·Carlo Contoreggi
Oct 5, 2016·Accounts of Chemical Research·Aleksandra S TsarkovaIlia V Yampolsky
Sep 24, 2013·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Luís Pinto da Silva, Joaquim C G Esteves da Silva

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
bioluminescence imaging
light scattering

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Related Papers

Nature Biotechnology
Jérôme Lecoq, Mark J Schnitzer
Medicine and Science in Sports and Exercise
Paul RobachJean-Paul Richalet
The Annals of Thoracic Surgery
Patricia A Thistlethwaite
© 2022 Meta ULC. All rights reserved