Imaging neurodegeneration in Down syndrome: brain templates for amyloid burden and tissue segmentation

Brain Imaging and Behavior
Patrick J LaoBradley T Christian

Abstract

The focus of Alzheimer's disease (AD) neuroimaging research has shifted towards an investigation of the earliest stages of AD pathogenesis, which manifests in every young adult with Down syndrome (DS; trisomy 21) resulting from a deterministic genetic predisposition to amyloid precursor protein overproduction. Due to morphological differences in brain structure in the DS population, special consideration must be given to processing pipelines and the use of normative atlases developed for the non-DS population. Further, the use of typical MRI to MRI template spatial normalization is less desirable in this cohort due to a greater presence of motion artefacts in MRI images. The diffuse nature of PiB uptake and comparatively lower spatial resolution of the PET image permits the purposing of this modality as a template for spatial normalization, which can substantially improve the robustness of this procedure in the cases of MRI images with motion. The aim of this work was to establish standardized methods for spatial normalization and tissue type segmentation using DS specific templates in order to perform voxel-wise analyses. A total of 72 adults with DS underwent [11C]PiB PET to assess brain amyloid burden and volumetric MRI imag...Continue Reading

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Citations

Jul 7, 2019·Developmental Neurobiology·María Carmona-IraguiJuan Fortea
Aug 6, 2019·Developmental Neurobiology·Eric E AbrahamsonMilos D Ikonomovic
Feb 13, 2020·Current Opinion in Psychiatry·Eimear McGlincheyMary McCarron
May 13, 2020·Frontiers in Human Neuroscience·Maria Carbó-CarretéJoan Guàrdia-Olmos
May 22, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Matthew D ZammitBradley T Christian
Dec 5, 2019·ACS Chemical Neuroscience·Wei-Quan FangMing-Jang Chiu

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Software Mentioned

AIR
Statistical Parametric Mapping toolbox ( SPM
SPM
ITK
SNAP
MATLAB

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