PMID: 8988622Jan 1, 1997Paper

Imaging objects in tissuelike media with optical tagging and the diffuse photon differential transmittance

Journal of the Optical Society of America. A, Optics, Image Science, and Vision
X D ZhuX W Guo

Abstract

In a proof-of-concept experiment, we optically tagged objects embedded in an inhomogeneous and multiple-scattering medium and measured the difference between the transmitted diffuse photons at two optical wave-lengths, one at and the other off a sharp absorption peak of the exogenous contrast agent. We demonstrated that the visibility of tagged objects was significantly enhanced in comparison with that of untagged objects. From our analysis it seems possible to use dual-wavelength differential transmittance spectrometry together with monoclonal-antibody-delivered optical contrast agents to detect tumors as small as 0.1-0.3 cm in size and embedded as deeply as a few centimeters beneath a tissue surface.

References

Oct 1, 1992·Journal of the Optical Society of America. A, Optics and Image Science·J M SchmittJ R Knutson
Apr 1, 1988·Journal of Biomedical Engineering·H KeyP N Wells
Feb 1, 1984·AJR. American Journal of Roentgenology·R J Bartrum, H C Crow
Jul 1, 1981·The Journal of Audiovisual Media in Medicine·R Morton, S S Miller
Jan 1, 1994·Breast Cancer Research and Treatment·K Orang-KhadiviR F Williams
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·D A BoasA G Yodh
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·B ChanceE Sevick
Jan 1, 1996·Medical Physics·S FantiniM Kaschke
Mar 1, 1988·Physical Review. B, Condensed Matter· van der Mark MBA Lagendijk
May 1, 1993·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·D A BoasA G Yodh
Dec 17, 1990·Physical Review Letters·R Berkovits, S Feng
Nov 1, 1991·Applied Optics·H J van StaverenM J van Gemert

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Citations

Feb 24, 2001·Neoplasia : an International Journal for Oncology Research·D J Hawrysz, E M Sevick-Muraca
Nov 23, 2000·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·D L EverittX D Zhu

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