Imaging of acute myocardial infarction by magnetic resonance tomography (MRT) using the paramagnetic relaxation substance gadolinium-DTPA

Cardiovascular Drugs and Therapy
H W EichstaedtH Schmutzler

Abstract

Twenty-six patients admitted to the Free University of Berlin University Hospital catheterization laboratory with acute myocardial infarction were studied. The diagnosis was confirmed by angiography, but acute revascularization was unsuccessful in every case. MR imaging was performed within 7 days of the acute event in 11 patients with uncomplicated clinical courses after acute infarction. Imaging was performed within 3 weeks in three additional cases, while the remaining 12 patients underwent studies more than 3 weeks after infarction. We determined signal intensity at three points within the area of infarction and at three other points in adjacent myocardial tissue. Decreased signal intensity within the area of infarction was found in native scans in 60% of all cases. Administration of gadolinium-DTPA 0.1 mmol/kg body weight was followed by a mean 70% increase in signal intensity within the zones of acute infarction, as compared to a 20% increase in surrounding myocardial tissue. In cases of subacute and chronic infarction, there was no significant signal enhancement after administration of gadolinium-DTPA. Uptake of the substance in the area of acute infarction may be a positive marker of acute myocardial necrosis and as suc...Continue Reading

References

Apr 28, 1977·The New England Journal of Medicine·L D Hillis, E Braunwald
Jul 1, 1979·Circulation·F R CobbC C Roe
Nov 1, 1977·British Heart Journal·A P SelwynJ P Shillingford
Apr 1, 1978·The Journal of Clinical Investigation·S F VatnerP R Maroko
May 1, 1975·The American Journal of Cardiology·M M BodenheimerR H Helfant
Nov 1, 1975·Circulation·R RobertsB E Sobel
Aug 1, 1985·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A R Margulis, M R Fisher
Mar 1, 1985·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·E ZeitlerH von Wulfen
Aug 1, 1984·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·W SchörnerR Felix
Oct 1, 1981·Journal of Computer Assisted Tomography·R C HawkesB S Worthington

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Citations

Oct 19, 2011·Pediatric Radiology·Edythe B ThamMichelle L Noga
Oct 8, 2009·Circulation. Arrhythmia and Electrophysiology·Saman NazarianHenry R Halperin
Jun 2, 2004·Journal of Magnetic Resonance Imaging : JMRI·Louise E J ThomsonRobert M Judd
Jul 10, 2013·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Henry G HockingTobias Madl
Jun 12, 2003·Magnetic Resonance Imaging Clinics of North America·Anja WagnerRobert M Judd
May 5, 2020·NMR in Biomedicine·Juliet VargheseOrlando P Simonetti
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Wenguang Li

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