Imaging of angiogenesis: from microscope to clinic

Nature Medicine
Donald M McDonald, Peter L Choyke

Abstract

Advances in imaging are transforming our understanding of angiogenesis and the evaluation of drugs that stimulate or inhibit angiogenesis in preclinical models and human disease. Vascular imaging makes it possible to quantify the number and spacing of blood vessels, measure blood flow and vascular permeability, and analyze cellular and molecular abnormalities in blood vessel walls. Microscopic methods ranging from fluorescence, confocal and multiphoton microscopy to electron microscopic imaging are particularly useful for elucidating structural and functional abnormalities of angiogenic blood vessels. Magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), ultrasonography and optical imaging provide noninvasive, functionally relevant images of angiogenesis in animals and humans. An ongoing dilemma is, however, that microscopic methods provide their highest resolution on preserved tissue specimens, whereas clinical methods give images of living tissues deep within the body but at much lower resolution and specificity and generally cannot resolve vessels of the microcirculation. Future challenges include developing new imaging methods that can bridge this resolution gap and specifically ide...Continue Reading

References

Dec 1, 1992·Cell and Tissue Research·V NehlsD Drenckhahn
Dec 4, 1992·Annals of the New York Academy of Sciences·H F DvorakD R Senger
Apr 1, 1991·The Journal of Cell Biology·V Nehls, D Drenckhahn
May 1, 1985·The Journal of Cell Biology·N C JoyceG E Palade
Jun 1, 1995·Pathology, Research and Practice·D Schmidt, A R von Hochstetter
Apr 1, 1994·Clinical and Experimental Immunology·V L BurgioC D Baroni
Oct 1, 1995·The Journal of Clinical Investigation·P C BrooksD A Cheresh
Feb 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R Timpl, J C Brown
Aug 1, 1996·The Journal of Pathology·R O SchlingemannD J Ruiter
Dec 1, 1996·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·H C LichtenbeldR K Jain
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·T M SchlaegerT N Sato
Jun 1, 1997·Nature Biotechnology·R PasqualiniE Ruoslahti
Apr 29, 1998·The Journal of Clinical Investigation·G ThurstonD M McDonald
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S K HobbsR K Jain
Apr 17, 1998·Cancer Metastasis Reviews·D Fukumura, R K Jain
Jul 4, 1998·Ultrasonics·F ForsbergB B Goldberg
Jul 4, 1998·European Journal of Radiology·F CalliadaM G Sommaruga
Aug 15, 1998·Seminars in Nuclear Medicine·T F Budinger
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·R K JainE Keshet
Nov 24, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C A MitchellH C Drexler
Aug 14, 1999·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·A C FleischerC G Hellerqvist
Sep 17, 1999·The American Journal of Pathology·A J ManiotisM J Hendrix
Dec 22, 1999·International Journal of Cancer. Journal International Du Cancer·M LewinR Weissleder
Mar 30, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S BredowR Weissleder
Apr 7, 2000·The American Journal of Pathology·H HashizumeD M McDonald
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·A BogdanovR Weissleder
Aug 19, 2000·Science·B St CroixK W Kinzler
Sep 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S A AndersonJ J Kotyk

❮ Previous
Next ❯

Citations

Jul 19, 2008·Analytical and Bioanalytical Chemistry·Katia WehbeCyril Petibois
Jun 8, 2010·Analytical and Bioanalytical Chemistry·Chia-Chi ChienG Margaritondo
Apr 2, 2011·Analytical and Bioanalytical Chemistry·Razia NoreenCyril Petibois
Jun 2, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Jiyun ShiShuang Liu
May 13, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Fabian KiesslingFrauke Alves
May 13, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Zhuang Liu, Rui Peng
Jul 28, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Mark H Michalski, Xiaoyuan Chen
Aug 17, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Ashley M GrovesMohammed R Keshtgar
Dec 3, 2008·Abdominal Imaging·Bernard E Van Beers, Valérie Vilgrain
Sep 19, 2009·Abdominal Imaging·Yan ChenChunwu Zhou
Jun 17, 2010·Cancer Immunology, Immunotherapy : CII·Stanisław SzalaAleksander Sochanik
Jun 4, 2011·Cancer Chemotherapy and Pharmacology·Domenico Ribatti
Nov 7, 2008·Histochemistry and Cell Biology·Girieca Lorusso, Curzio Rüegg
May 7, 2008·Langenbeck's Archives of Surgery·José Tomás EgañaHans-Günther Machens
Aug 4, 2007·Journal of Digital Imaging·George C KagadisGeorge C Nikiforidis
May 9, 2012·Annals of Biomedical Engineering·Eugene KimArvind P Pathak
Dec 21, 2004·Angiogenesis·Ugur Ozerdem, William B Stallcup
May 12, 2005·Angiogenesis·Ugur Ozerdem
Oct 18, 2008·Angiogenesis·Arvind P PathakMichael S Pepper
Jun 19, 2010·Angiogenesis·Willem J M Mulder, Arjan W Griffioen
Mar 23, 2012·Breast Cancer Research and Treatment·Karine MahéoCaroline Goupille
Apr 17, 2008·Cancer Metastasis Reviews·Aaron P BrownKevin A Camphausen
Jun 5, 2008·Cancer Metastasis Reviews·Ambros J Beer, Markus Schwaiger
Nov 1, 2007·Clinical & Experimental Metastasis·Colm MorrisseyRobert L Vessella
May 2, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Antje DietrichLeoni A Kunz-Schughart
May 13, 2009·Medical & Biological Engineering & Computing·Eleanor Stride, Mohan Edirisinghe
Aug 1, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·José L OrgazBenilde Jiménez
Apr 20, 2004·The International Journal of Biochemistry & Cell Biology·M Luisa Iruela-ArispeNathan Lee
May 4, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G Taraboletti, R Giavazzi
Oct 15, 2003·Trends in Molecular Medicine·Lily WuMakoto Sato
Mar 30, 2004·Ultrasonics·F ForsbergL N Nazarian
Sep 24, 2013·Experimental Cell Research·Bita CarrionAndrew J Putnam
Jan 2, 2013·Chemical Reviews·Venkat Ratnam DevadasuM N V Ravi Kumar

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