Imaging of calcium pyrophosphate deposition disease

Current Rheumatology Reports
Jennifer Miksanek, A K Rosenthal

Abstract

Calcium pyrophosphate deposition disease (CPPD) is a common and clinically heterogeneous form of arthritis caused by the deposition of calcium pyrophosphate (CPP) crystals in articular tissues. The diagnosis of CPPD is supported by the presence of radiographic chondrocalcinosis; yet, conventional radiography detects only about 40 % of clinically important CPPD. Here, we critically review the recent literature on imaging in CPPD. New studies inform our use of conventional radiographic screening methodologies for CPPD and provide additional evidence for the utility of diagnostic ultrasound. Recent work also highlights the polyarticular nature of CPPD, its association with tissue damage, and the high prevalence of tendon involvement. While dual energy CT and diffraction-enhanced synchrotron imaging remain research tools, they present potential avenues for improved visualization of CPP deposits. Advances in imaging in CPPD will increase diagnostic accuracy and eventually result in better management of this common form of arthritis.

References

Jan 1, 1992·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·A Fisseler-Eckhoff, K M Müller
Sep 1, 1989·Annals of the Rheumatic Diseases·C GordonP Dieppe
Dec 21, 2005·Clinical Rheumatology·J C GersterA K L So
Aug 29, 2009·Arthritis and Rheumatism·M FuerstW Rüther
Dec 24, 2011·Rheumatology International·Abdou S EllabbanRasha A Abdel-Magied
Mar 1, 2012·Acta neurochirurgica·Vasisht SrinivasanKevin Walter
Jun 8, 2012·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·J LiC Muehleman
Oct 6, 2012·Arthritis Research & Therapy·Abhishek AbhishekMichael Doherty
Jun 6, 2013·Radiology·Eric Y ChangDonald L Resnick
Jun 29, 2013·Neuro-Chirurgie·M Godfrin-ValnetD Wendling
Oct 12, 2013·Arthritis Care & Research·Marwin GutierrezWalter Grassi
Mar 29, 2014·Annals of the Rheumatic Diseases·Tim BongartzCynthia H McCollough
May 23, 2014·The Korean Journal of Internal Medicine·Hae-Rim KimSang-Heon Lee

❮ Previous
Next ❯

Citations

Jun 30, 2016·The New England Journal of Medicine·Ann K Rosenthal, Lawrence M Ryan
Apr 7, 2018·Journal of Orthopaedic Surgery and Research·Hidenori TanikawaTakeo Nagura
Sep 26, 2019·Radiology and Oncology·Bilal MujtabaRizwan Aslam
Aug 2, 2017·Physics in Medicine and Biology·F HornG Anton
May 27, 2016·JAAPA : Official Journal of the American Academy of Physician Assistants·Thomas Rosen, Janet Furman
Dec 15, 2020·Ultrasonography·Christoph SchwablAndrea S Klauser
Jun 4, 2021·Seminars in Musculoskeletal Radiology·Stephen ScullionAdam Greenspan
Aug 22, 2021·Calcified Tissue International·Rebecca F ShepherdAdam M Taylor
Oct 9, 2021·Current Rheumatology Reports·Jeremy SullivanMichael Toprover

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.