PMID: 9544665Apr 17, 1998Paper

Imaging of cerebral blood flow with technetium-99m-HMPAO and technetium-99m-ECD: a comparison

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
S AsenbaumI Podreka

Abstract

Because 99mTc-HMPAO and 99mTc-ECD are both used for SPECT imaging of cerebral blood flow, the question arises whether there are any differences in their respective regional cerebral distribution. For that purpose, visual and semiquantitative comparisons between 99mTc-HMPAO and 99mTc-ECD studies were performed. Seventeen patients (4 women; 13 men; age 45-89 yr; mean age 71 yr) with various neurological diseases, except acute/subacute stroke, were investigated twice with 99mTc-HMPAO and 99mTc-ECD using a triple-headed rotating SPECT camera. After image reorientation, the two studies were evaluated visually. Seventy regions of interest (ROIs) were drawn manually and the same set of ROIs was applied in both studies. Regional indices (RI) normalized to individual brain values were calculated and first compared between two random patient groups. Second, for all patients, RI for 70 and later for 27 regions (gained after summing values of corresponding regions in different brain slices) were compared by using a paired Student's t-test applying Bonferroni's correction. Visual evaluation demonstrated relatively high 99mTc-ECD uptake in occipital and comparatively low uptake in mediotemporal regions. Calculation of RI revealed significant...Continue Reading

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