Imaging of Early Response to Predict Prognosis in the First-Line Management of Follicular Non-Hodgkin Lymphoma with Iodine-131-Rituximab Radioimmunotherapy

Diagnostics
Murali KesavanJ Harvey Turner

Abstract

The purpose of this study was to evaluate prediction of prognosis after first-line radioimmunotherapy (RIT) of advanced follicular non-Hodgkin lymphoma (FL), by imaging with fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography ((18)F-FDG-PET/CT) three months after induction treatment by Iodine-131-rituximab ((131)I-rituximab). Objective response was determined using the Deauville 5-point scale in 68 prospective clinical trial patients. Baseline (18)F-FDG-PET/CT studies were used to calculate total-metabolic-tumor-volume (TMTV). Non-imaging studies included the Follicular lymphoma international prognostic index (FLIPI) and absolute baseline monocyte and lymphocyte counts. Patients were monitored for over ten years (median follow-up 59 months), and no patient was lost to follow-up. Complete response (CR) of 88% predicted excellent prognosis with median time-to-next-treatment (TTNT) not yet reached. Those patients (12%) who failed to achieve CR (Deauville ≤ 3) on (18)F-FDG-PET/CT at three months had significantly poorer outcomes (p < 0.0001) with a median TTNT of 41 months. Requirement for re-treatment was predicted by FLIPI and absolute baseline monocyte count but not lymphocyte count. The TTNT was...Continue Reading

References

May 6, 2004·Blood·Philippe Solal-CélignyEmili Montserrat
Aug 8, 2006·British Journal of Haematology·Mustaqeem SiddiquiLuis F Porrata
Aug 19, 2006·Current Treatment Options in Oncology·Philippe Solal-Celigny
Jul 16, 2008·Radiologic Clinics of North America·Bruce D Cheson
Aug 5, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Massimo FedericoPhilippe Solal-Céligny
Jun 19, 2012·Journal of Clinical and Experimental Hematopathology : JCEH·Ayumi NumataYoshiaki Ishigatsubo
Mar 27, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Massimo FedericoMaura Brugiatelli
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonT Andrew Lister
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sally F BarringtonBruce D Cheson
Dec 21, 2014·Blood·Stephen D SmithKieron Dunleavy
Aug 11, 2015·The Lancet Oncology·Armando López-Guillermo
Mar 19, 2016·Blood·Brad S Kahl, David T Yang
Apr 30, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mateen C MoghbelErik Mittra
Aug 24, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michel MeignanJudith Trotman
Nov 24, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mateen C MoghbelLale Kostakoglu
Dec 29, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michel MeignanJudith Trotman
Dec 29, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Laffon, Roger Marthan

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

SPSS

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.