Imaging of gadolinium spatial distribution in tumor tissue by laser ablation inductively coupled plasma mass spectrometry.

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Nazila KamalyJimmy Bell

Abstract

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was utilized in postmortem imaging of gadolinium (Gd) spatial distribution in a mouse tumor model postadministration of PEGylated Gd liposomal nanoparticles. PEGylated liposomal nanoparticles were formulated using a paramagnetic lipid incorporating Gd, in addition to a fluorescent lipid, and injected intravenously into Balb/C nude mice bearing IGROV-1 tumors. At postinjection (2 h), the tumors and selective organs were imaged by magnetic resonance imaging (MRI) and, after excision, by histology and LA-ICP-MS. The presence of Gd within tumor tissue was confirmed by LA-ICP-MS and when correlated to histology was found to be prevalent in regions of higher vascularity. The presence of Gd in the kidneys was also confirmed. We have demonstrated, in a novel manner, the use of LA-ICP-MS for the spatial detection of Gd in tumor tissue. LA-ICP-MS is valuable in providing spatio-specific information of MRI contrast agents and more importantly Gd in tumor tissue.

References

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Oct 13, 2006·Organic & Biomolecular Chemistry·Morag OliverMichael R Jorgensen
Jul 7, 2007·The AAPS Journal·Vladimir P Torchilin
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Apr 17, 2009·Bioconjugate Chemistry·Nazila KamalyAndrew D Miller

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Citations

Apr 25, 2012·Analytical and Bioanalytical Chemistry·J A T PughJ Bell
Jun 6, 2013·Journal of Drug Delivery·M Thanou, W Gedroyc
Sep 24, 2015·Mass Spectrometry Reviews·Alessandra SussuliniJohanna Sabine Becker
Apr 1, 2015·Molecular Pharmaceutics·Elena V RoscaMaya Thanou
Jun 13, 2012·Alimentary Pharmacology & Therapeutics·G BrakmaneA M Seifalian
Nov 21, 2018·Analytical and Bioanalytical Chemistry·Sabrina TrogMichael W Linscheid

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