Abstract
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was utilized in postmortem imaging of gadolinium (Gd) spatial distribution in a mouse tumor model postadministration of PEGylated Gd liposomal nanoparticles. PEGylated liposomal nanoparticles were formulated using a paramagnetic lipid incorporating Gd, in addition to a fluorescent lipid, and injected intravenously into Balb/C nude mice bearing IGROV-1 tumors. At postinjection (2 h), the tumors and selective organs were imaged by magnetic resonance imaging (MRI) and, after excision, by histology and LA-ICP-MS. The presence of Gd within tumor tissue was confirmed by LA-ICP-MS and when correlated to histology was found to be prevalent in regions of higher vascularity. The presence of Gd in the kidneys was also confirmed. We have demonstrated, in a novel manner, the use of LA-ICP-MS for the spatial detection of Gd in tumor tissue. LA-ICP-MS is valuable in providing spatio-specific information of MRI contrast agents and more importantly Gd in tumor tissue.
References
Dec 26, 2001·Chemical Reviews·P CaravanR B Lauffer
Jun 5, 2003·Analytical Biochemistry·Marie R B BinetRobert K Poole
Aug 10, 2004·Electrophoresis·Renli MaRobert K Poole
Jul 6, 2005·Analytical and Bioanalytical Chemistry·Victoria L ElliottPeter S Marshall
Oct 11, 2005·Analytical Biochemistry·Robert W HutchinsonDavid R Howlett
Oct 13, 2006·Organic & Biomolecular Chemistry·Morag OliverMichael R Jorgensen
Jul 7, 2007·The AAPS Journal·Vladimir P Torchilin
Nov 8, 2007·Bioconjugate Chemistry·Nazila KamalyAndrew D Miller
Mar 29, 2008·Talanta·J DobrowolskaJ S Becker
Jul 8, 2008·Analytica Chimica Acta·J MillosC Bendicho
Aug 13, 2008·Rapid Communications in Mass Spectrometry : RCM·J Sabine BeckerAndreas Matusch
Aug 21, 2008·Proteomics·Jaume SeumaCliff Murray
Sep 2, 2008·Talanta·J Susanne BeckerRyszard Lobinski
Feb 11, 2009·Electrophoresis·Andrea RaabJörg Feldmann
Mar 14, 2009·Analytical Chemistry·Elena AcquadroDavide Corpillo
Apr 17, 2009·Bioconjugate Chemistry·Nazila KamalyAndrew D Miller
Citations
Apr 25, 2012·Analytical and Bioanalytical Chemistry·J A T PughJ Bell
Oct 5, 2012·Nanoscale Research Letters·Gholamreza AzizianEnsieh Gorji
Jun 6, 2013·Journal of Drug Delivery·M Thanou, W Gedroyc
Jun 24, 2014·Analytica Chimica Acta·J Sabine BeckerBei Wu
Aug 11, 2012·Journal of Neuropathology and Experimental Neurology·Pablo A ValdésBrent T Harris
Oct 3, 2012·Small·Xiao HeZhiyong Zhang
Mar 17, 2016·The Analyst·S Gokhan ElciRichard W Vachet
Jan 3, 2013·Contrast Media & Molecular Imaging·Alessandra SussuliniJ Sabine Becker
Sep 24, 2015·Mass Spectrometry Reviews·Alessandra SussuliniJohanna Sabine Becker
Mar 21, 2015·Analytical Chemistry·Olga ReifschneiderUwe Karst
Feb 25, 2015·Analytical Chemistry·Marvin BirkaUwe Karst
Apr 1, 2015·Molecular Pharmaceutics·Elena V RoscaMaya Thanou
Oct 2, 2013·Analytical Chemistry·Amy J ManaghBarry L Sharp
Jun 13, 2012·Alimentary Pharmacology & Therapeutics·G BrakmaneA M Seifalian
Nov 21, 2018·Analytical and Bioanalytical Chemistry·Sabrina TrogMichael W Linscheid
Sep 27, 2019·Nano Letters·Max MasthoffCornelius Faber
Apr 9, 2020·Analytical Chemistry·Juan HeJuris Meija