Imaging of hyperalgesia in rats by functional MRI

European Journal of Pain : EJP
Andreas HessKay Brune

Abstract

Cerebral activation in response to sequences of temperature boosts at the hindpaw was observed in functional magnetic resonance imaging (fMRI) experiments in isoflurane anesthetized rats. Cingulate, retrosplenial, sensory-motor and insular cortex, medial and lateral posterior thalamic nuclei, pretectal area, hypothalamus and periaqueductal gray were the most consistently, often bilaterally activated regions. With the same experimental paradigm, activity changes in the brain following subcutaneous zymosan injection into one hindpaw were detected. These changes developed over time (up to 4h) in parallel with the temporal development of hyperalgesia shown by a modified Hargreaves test, thus reflecting processes of peripheral and central sensitization. When the heat stimuli were applied to the inflamed paw, the hyperalgesia manifested itself as a volume increase of the activated areas and/or an enhanced functional blood oxygenation level dependent (BOLD) signal in all the above-mentioned brain regions. Enhanced BOLD signals were also observed in response to stimulation of the contralateral non-injected paw. They were significant in higher associative regions and more pronounced in output-related than in input-related brain structur...Continue Reading

References

Mar 1, 1990·Trends in Neurosciences·R Melzack
Aug 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M UekiK A Hossmann
Sep 25, 1986·Neuroscience Letters·S R Cohen, R Melzack
Dec 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J HennigH Friedburg
Feb 1, 1995·Brain : a Journal of Neurology·O DevinskyB A Vogt
Jul 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F HyderR G Shulman
Dec 20, 1993·Behavioural Brain Research·J H MedinaI Izquierdo
Aug 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A BandettiniJ S Hyde
Jul 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M L GyngellK A Hossmann
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·R PórszászM Rudin
Jun 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B E ScanleyJ C Gore
Jun 1, 1997·Journal of Neurophysiology·K D DavisD J Mikulis
May 14, 1998·The British Journal of Radiology·A P JonesA K Jones
Dec 24, 1998·Journal of Neurophysiology·C A PorroP Baraldi
Mar 6, 1999·Pain·R D TreedeA K Jones
Apr 2, 1999·The European Journal of Neuroscience·C A PorroR Corazza
Apr 13, 1999·Trends in Neurosciences·M KoltzenburgS B McMahon
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·K L Casey
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·M C BushnellB Carrier
Feb 17, 2000·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A J Hudson
Dec 29, 2000·Neurophysiologie clinique = Clinical neurophysiology·R PeyronL García-Larrea
Apr 6, 2001·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·H GühringG Geisslinger
Oct 13, 2001·Journal of Magnetic Resonance Imaging : JMRI·K L Malisza, J C Docherty
Jan 16, 2002·Pain·Predrag Petrovic, Martin Ingvar
Aug 6, 2002·Neuron·Jürgen LorenzKenneth L Casey
Feb 20, 2003·Magnetic Resonance Imaging·U I TuorB Tomanek
Jul 25, 2003·Magnetic Resonance Imaging·Krisztina L MaliszaAnthony Wright
Jun 26, 2004·The European Journal of Neuroscience·Christian MaihöfnerHermann O Handwerker
Jul 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bai-Chung ShyuChen Chang

❮ Previous
Next ❯

Citations

Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Andreas HessGeorg Schett
Jun 9, 2012·BMC Neuroscience·Dave J Hayes, Georg Northoff
Dec 18, 2013·Protoplasma·Danny HamersJoachim Goedhart
Jun 6, 2006·The Journal of Pharmacology and Experimental Therapeutics·S S NegusD Borsook
Dec 4, 2015·NeuroImage·Saeedeh AmirmohseniEsther Pogatzki-Zahn
Feb 12, 2011·Expert Review of Gastroenterology & Hepatology·Daniel P HolschneiderEmeran A Mayer
Sep 1, 2008·Expert Opinion on Drug Discovery·Daniel N CortrightDaniel C Broom
Mar 27, 2012·Neuroscience Letters·Scott J Thompson, M Catherine Bushnell
Dec 21, 2010·The Journal of Pain : Official Journal of the American Pain Society·Gláucia Melo ReisWiliam A Prado
Jan 12, 2011·Biochemical Pharmacology·Unal SakoğluFeng Luo
Dec 4, 2010·Neuroscience and Biobehavioral Reviews·David Borsook, Lino Becerra
Apr 27, 2010·The Journal of Pain : Official Journal of the American Pain Society·Glaucia Melo ReisWiliam A Prado
Aug 18, 2009·Neuroscience Letters·Myeoung Hoon ChaBae Hwan Lee
Oct 15, 2008·Neurobiology of Disease·Pedro AlvarezRadhouane Dallel
Jul 14, 2010·European Journal of Pain : EJP·Ulises CoffeenFrancisco Pellicer
Jul 17, 2013·European Journal of Pain : EJP·B A HookerJ Upadhyay
Sep 20, 2011·Pharmacology, Biochemistry, and Behavior·Ana Carolina RossaneisWiliam A Prado
Nov 15, 2007·NeuroImage·David M NiddamJen-Chuen Hsieh
Jul 5, 2008·NeuroImage·David BorsookLino Becerra
Feb 9, 2012·Journal of Acupuncture and Meridian Studies·Marcelo L SilvaWiliam A Prado
Aug 7, 2013·Toxicon : Official Journal of the International Society on Toxinology·S Wolz-RichterA Hess
Feb 16, 2007·NeuroImage·Andrew S LoweSteve C R Williams
Oct 26, 2016·Neuroscience Letters·Jeongsoo HanBae Hwan Lee
Apr 22, 2008·British Journal of Anaesthesia·P Flecknell
Jan 19, 2008·Nature·Julia KnablHanns Ulrich Zeilhofer
Feb 6, 2014·Cambridge Quarterly of Healthcare Ethics : CQ : the International Journal of Healthcare Ethics Committees·Tom Buller
Feb 11, 2020·Frontiers in Neuroinformatics·Francesca MandinoJoanes Grandjean
Mar 19, 2019·Current Opinion in Supportive and Palliative Care·Ana David-Pereira, Anthony H Dickenson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.