PMID: 9553163May 30, 1998Paper

Imaging of infection in rabbits with radioiodinated interleukin-1 (alpha and beta), its receptor antagonist and a chemotactic peptide: a comparative study

European Journal of Nuclear Medicine
C J van der LakenF H Corstens

Abstract

Previous studies have reported the favourable characteristics of chemotactic peptides and interleukins for imaging of infection and inflammation. In the present study, the potential of two species of interleukin 1 (IL-1), IL-1alpha and IL-1beta, the IL-1 receptor antagonist (IL-1ra) and the synthetic chemotactic peptide N-formyl-methionyl-leucyl-phenylalanyl-lysine (fMLFK) were directly compared in a rabbit model of infection. IL-1alpha, IL-1beta, IL-1ra and fMLFK were labelled with iodine-123 according to the Bolton-Hunter method. Twenty-four hours after induction of Escherichia coli abscesses in the left thigh muscle, rabbits were injected intravenously with 0.5 mCi of 123I-labelled agent. Gamma camera images were obtained at 5 min and 1, 4, 8 and 20 h p.i. Biodistribution was determined at 20 h p.i. Although all agents rapidly cleared from the blood, at 20 h p.i. blood levels and the levels in most organs of 123I-fMLFK were significantly lower than those of the other three agents (P<0.05). The abscesses were clearly visualized with all agents from 4 h p.i. onwards. After 1 h p.i., the abscess uptake of 123I-IL-1beta was significantly higher than that of the other agents (P<0.05), with the highest uptake observed at 8 h p.i. ...Continue Reading

Citations

Mar 23, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Andor W J M GlaudemansAlberto Signore
Aug 13, 2011·Annals of Nuclear Medicine·Alberto Signore, Andor W J M Glaudemans
Jun 6, 2000·Advanced Drug Delivery Reviews·J W Babich, A J Fischman
Feb 24, 2001·Nuclear Medicine Communications·A H BrouwersF H Corstens
Aug 16, 2001·Nuclear Medicine Communications·S GratzW Becker
Aug 19, 2003·Annals of the Rheumatic Diseases·P BarreraP L C M van Riel
Aug 28, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Alberto SignoreFrancesco Scopinaro
Mar 6, 2015·TheScientificWorldJournal·Chris Tsopelas
Oct 23, 2004·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·J K AmarteyR S Parhar
Aug 6, 2000·Seminars in Nuclear Medicine·O C BoermanF H Corstens
Dec 26, 2001·Chemical Reviews·S Liu, D S Edwards
Nov 2, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Zhonglin LiuJames M Woolfenden
Apr 14, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Valentina Di GialleonardoErik F J De Vries
May 4, 2010·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·C PrenantH Boutin

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