Imaging of liver disease: comparison between quadruple-phase multidetector computed tomography and magnetic resonance imaging

Journal of Gastroenterology and Hepatology
N Cem BalciNecat Havlioglu

Abstract

To compare quadruple-phase multidetector computed tomography (MDCT) and magnetic resonance imaging (MRI) for the assessment of focal and diffuse liver disease. Quadruple-phase contrast-enhanced MDCT and MRI of 37 consecutive patients were retrospectively reviewed by two readers (R1 and R2). In patients with focal liver lesions, the gold standard was histopathology (n = 17) and/or long-term (>6 months) follow-up imaging (n = 27) or transarterial chemoembolization (n = 1). Diffuse liver disease was confirmed by histopathology in all patients, when present. Both readers identified 60 focal liver lesions on MDCT and 56 focal liver lesions on MRI. Gold standard diagnoses revealed 48 focal liver lesions in 25 patients. Diagnosis of malignant liver lesions revealed a sensitivity of 88% (R1) and 91% (R2) for MRI; 63% (R1) and 66% (R2) for MDCT; and a specificity of 75% (R1) and 79% (R2) for MRI; 50% (R1) and 64% (R2) for MDCT. MRI was superior to MDCT for the diagnosis of malignant focal liver lesions, when the mean areas under the alternative free-response receiver operating characteristic curves (A(Z)) were compared (MRI = 0.93 vs CT = 0.69), (P < 0.00001). Thirty-three patients had histopathologically confirmed diffuse liver disease...Continue Reading

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Citations

Jan 6, 2009·Journal of Gastroenterology and Hepatology·Osamu MatsuiSatoshi Kobayashi
Jul 15, 2009·World Journal of Gastroenterology : WJG·Nimer AssyJamal Zidan
May 9, 2012·Medical Physics·Eliana M Vasquez OsorioBen J M Heijmen
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Feb 18, 2014·Computer Methods and Programs in Biomedicine·F López-MirL Luna
Jan 13, 2015·Scandinavian Journal of Gastroenterology·Pekka CollinJuhani Sand

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