Imaging of low-grade bone infection with a technetium-99m labelled monoclonal anti-NCA-90 Fab' fragment in patients with previous joint surgery

European Journal of Nuclear Medicine and Molecular Imaging
V IvancevicV Ivanèeviae

Abstract

Low-grade bone infection represents a serious clinical problem. Diagnostic options are often insufficient, yet the therapeutic implications of proven disease are important, especially in patients with prosthetic joint replacement. Technetium-99m labelled monoclonal anti-NCA-90 granulocyte antibody Fab' fragment (MN3 Fab') has been shown to be useful in bone and joint infection, but there are no data specifically referring to low-grade bone infection. We therefore analysed 38 scans in 30 consecutive patients (age range, 30-85 years; median age, 62 years) referred for suspected low-grade bone infection. There were 17 patients (21 scans) with total hip arthroplasty (THA), six with total knee arthroplasty (TKA), three who had undergone hip or knee surgery for trauma and five (seven scans) with resected hips and no endoprostheses (Girdlestone situations); one of these five patients had been investigated before with THA in situ and another prior to surgery for low-grade coxitis. There were no patients with rheumatoid arthritis as the underlying disease. Results were verified by means of bacteriological cultures, histopathological findings and/or follow-up and compared with the respective Zimmerli scores, which were used for clinical ...Continue Reading

Citations

Mar 24, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Vera GrauteMarcus Hacker
Sep 18, 2007·Archives of Orthopaedic and Trauma Surgery·Björn ZappeParham Sendi
Aug 9, 2008·Current Infectious Disease Reports·Andrej Trampuz, Werner Zimmerli
Jan 7, 2005·The New England Journal of Medicine·Aaron E Glatt
Oct 16, 2004·The New England Journal of Medicine·Werner ZimmerliPeter E Ochsner
Apr 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph R Lentino
Jan 15, 2014·Der Orthopäde·T WinklerC Perka
Oct 20, 2018·Acta Orthopaedica·Stefan J GeldermanMarjan Wouthuyzen-Bakker
Feb 2, 2013·The International Journal of Artificial Organs·Parham Sendi, Werner Zimmerli
Oct 7, 2016·The Journal of Bone and Joint Surgery. American Volume·S J VerberneO P P Temmerman
Dec 29, 2020·The Journal of Bone and Joint Surgery. American Volume·John M PinskiJoseph J Kavolus
Nov 28, 2006·Best Practice & Research. Clinical Rheumatology·Werner Zimmerli

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