Imaging of medullary thyroid carcinoma

Der Radiologe
M Uhrig, Stefan Delorme

Abstract

About 10% of thyroid cancers are medullary thyroid carcinoma (MTC) and can occur sporadically, familially and in the context of type II multiple endocrine neoplasia (MEN). Imaging plays a pivotal role in screening family members and in diagnosis. Diagnosis is based on ultrasound (US), thyroid scintigraphy, serum calcitonin and carcinoembryonic antigen (CEA) as well as fine needle biopsy. High-resolution US is the most important imaging method for locoregional staging, combined with computed tomography (CT) of the mediastinum. Positron emission tomography (PET-CT) using 18-F-DOPA is particularly suited for suspected occult metastases in case of rising tumor markers in serum. Diagnosis is made based on cytologic findings in a hypoechoic, cold thyroid nodule, combined with an elevation of serum calcitonin and CEA. US is the most important imaging modality during routine follow-up. CT is indicated for suspected mediastinal, lung, or liver metastases. CT should be replaced by MRI as early as possible to prevent significant cumulative radiation doses over time. Although MTC is curable by surgery only, owing to its radio- and chemoresistance, the disease will often progress only slowly, and even patients with metastases will frequentl...Continue Reading

References

Jul 1, 1982·AJR. American Journal of Roentgenology·T A McCookS A Wells
Nov 10, 2000·Journal of Medical Genetics·J R Hansford, L M Mulligan
Dec 6, 2001·European Radiology·L SolbiatiM Tonolini
May 5, 2007·International Journal of Surgical Pathology·Maria P FoschiniLuciano Castaldini
Apr 9, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Ann D King
Sep 16, 2008·Thyroid : Official Journal of the American Thyroid Association·Vincenzo TriggianiEmilio Tafaro
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Mar 10, 2009·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Sung-Hun KimChan-Kwon Jung
Jan 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sami AntounVickie E Baracos
Jan 10, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Giorgio TregliaVittoria Rufini
Nov 23, 2013·AJR. American Journal of Roentgenology·Dhakshinamoorthy GaneshanChusilp Charnsangavej
May 23, 2014·AJR. American Journal of Roentgenology·Charles MarcusRathan M Subramaniam
Aug 12, 2014·World Journal of Gastroenterology : WJG·Vito CantisaniFerdinando D'Ambrosio
Sep 5, 2014·Endokrynologia Polska·Kosma WolińskiMarek Ruchała
Dec 30, 2014·Critical Reviews in Oncology/hematology·Pooja GhataliaGuru Sonpavde
Jan 2, 2015·Therapeutic Advances in Medical Oncology·T Alonso-GordoaEnrique Grande
Feb 1, 2015·European Journal of Endocrinology·Carole GuerinDavid Taïeb
Mar 27, 2015·Thyroid : Official Journal of the American Thyroid Association·Samuel A WellsUNKNOWN American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma
May 15, 2015·Ultrasonography·Jin Yong Sung
Oct 27, 2015·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Stefan Delorme, Friedhelm Raue
May 1, 2014·Ultrasound : Journal of the British Medical Ultrasound Society·M D'OnofrioR Pozzi Mucelli
Sep 3, 2016·Endocrinology and Metabolism·Bo Hyun Kim, In Joo Kim
Sep 13, 2016·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Tatiana KelilSree Harsha Tirumani
Mar 10, 2018·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·H Dralle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Related Papers

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer
Stefan Delorme, Friedhelm Raue
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Saila KauhanenPirjo Nuutila
© 2021 Meta ULC. All rights reserved