PMID: 11309099Apr 20, 2001Paper

Imaging of monolayers composed of palmitic acid and lung surfactant protein B

Journal of Microscopy
B N FlandersR C Dunn

Abstract

Near-field scanning optical microscopy and atomic force microscopy are used to probe the sub-micrometre phase structure in palmitic acid monolayers containing the 25 peptide amino terminus of lung surfactant protein B (SP-B(1-25)). Monolayers deposited onto mica substrates at a surface pressure of 15 mN m-1 exhibit a two-phase coexistence across a broad range of SP-B(1-25) concentrations. Monolayers containing 5 wt.% SP-B(1-25) or less exhibit an expanse of liquid condensed phase in which elliptical liquid expanded (LE) domains with areas of approximately 25 microm2 coexist. By contrast, monolayers containing 20 wt.% SP-B(1-25) exhibit an expanse of liquid expanded phase in which circular liquid condensed domains coexist. The phase distribution dependence on SP-B(1-25) concentration suggests that the peptide induces disorder in the monolayer.

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Citations

Oct 20, 2006·European Biophysics Journal : EBJ·Pariya Na NakornHans-Joachim Galla
Apr 2, 2003·Biophysical Journal·J Alfredo FreitesDouglas J Tobias
Apr 25, 2008·Biochimica Et Biophysica Acta·Yi Y ZuoFred Possmayer
Mar 14, 2007·Biochimica Et Biophysica Acta·Nilanjana BiswasRichard A Dluhy
Sep 28, 2014·Chemistry and Physics of Lipids·Elisa Parra, Jesús Pérez-Gil
Aug 26, 2006·Photochemistry and Photobiology·Gang Ma, Heather C Allen
Dec 13, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Gang Ma, Heather C Allen
Jul 27, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Anastasia Mardilovich, Efrosini Kokkoli

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