PMID: 9431508Feb 12, 1998Paper

Imaging of oxygen saturation and distribution of erythrocytes in microvessels

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
N TateishiN Maeda

Abstract

To construct images of oxygen saturation and the distribution of erythrocytes in a network of microvessels. The image of a small group of microvessels under an inverted microscope was incorporated into an image processor through a video camera and was digitized. Based on the information obtained through six visible interference filters of different wavelengths, oxygen saturation and the amount of erythrocytes in microvessels were calculated with a computer. The system was applied to a microvascular bed of isolated rabbit mesentery perfused with a suspension of human erythrocytes. In a steady flow, with lowering of tissue oxygen tension by superfusion with nitrogen-bubbled isotonic saline containing 20 mmol/L sodium dithionite, the decrease of oxygen saturation of erythrocytes from arterioles to venules was imaged. Simultaneously, the distribution of erythrocytes in the microvessels was imaged and the marginal cell-free layer was profiled under high magnification. No significant alteration of the erythrocyte distribution on the deoxygenation of erythrocytes was observed. The exposure of erythrocytes to acidic pH and the decrease of the flow velocity of erythrocytes increased the release of oxygen from the erythrocytes in microve...Continue Reading

Citations

May 3, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Thorsten Schwerte, Regina Fritsche
Feb 2, 2011·Acta Physiologica·R N Pittman
Apr 3, 2001·The Japanese Journal of Physiology·G McHedlishvili, N Maeda
Oct 3, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Roland N Pittman
Jul 26, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Hiromi SakaiEishun Tsuchida
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·N TateishiN Maeda
Feb 17, 2017·Journal of the Royal Society, Interface·B Zeller-PlumhoffP Schneider
Apr 5, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Roland N Pittman

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