Imaging of proteoglycan and water contents in human articular cartilage with full-body CT using dual contrast technique

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Miitu K M HonkanenJ Töyräs

Abstract

Assessment of cartilage composition via tomographic imaging is critical after cartilage injury to prevent post-traumatic osteoarthritis. Diffusion of cationic contrast agents in cartilage is affected by proteoglycan loss and elevated water content. These changes have opposite effects on diffusion and, thereby, reduce the diagnostic accuracy of cationic agents. Here, we apply, for the first time, a clinical full-body CT for dual contrast imaging of articular cartilage. We hypothesize that full-body CT can simultaneously determine the diffusion and partitioning of cationic and non-ionic contrast agents and that normalization of the cationic agent partition with that of the non-ionic agent minimizes the effect of water content and tissue permeability, especially at early diffusion time points. Cylindrical (d = 8 mm) human osteochondral samples (n = 45; four cadavers) of a variable degenerative state were immersed in a mixture of cationic iodinated CA4+ and non-charged gadoteridol contrast agents and imaged with a full-body CT scanner at various time points. Determination of contrast agents' distributions within cartilage was possible at all phases of diffusion. At early time points, gadoteridol, and CA4+ distributed throughout car...Continue Reading

References

May 1, 1970·Biophysical Journal·A Maroudas
Oct 1, 1980·Annals of the Rheumatic Diseases·A MaroudasM F Venn
May 1, 1995·The American Journal of Sports Medicine·C N van DijkR K Marti
Jun 29, 2004·Addictive Behaviors·Robert J BattjesTimothy W Kinlock
Sep 15, 2005·Archives of Biochemistry and Biophysics·Robin C Evans, Thomas M Quinn
Dec 13, 2005·European Radiology·Thomas G FlohrBernd M Ohnesorge
Jul 4, 2006·Biochimica Et Biophysica Acta·Xiaohong BiNancy Pleshko Camacho
Dec 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ashley W PalmerMarc E Levenston
Feb 1, 2007·Physics in Medicine and Biology·A S KallioniemiJ Töyräs
Oct 10, 2008·European Journal of Radiology·Martin PetersilkaThomas G Flohr
Jan 24, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin M KochKevin F King
Oct 10, 2009·Rheumatology International·Anne-Christine Bay-JensenMorten A Karsdal
Oct 30, 2009·Physics in Medicine and Biology·Tuomo S SilvastJuha Töyräs
Oct 5, 2010·Journal of Biomechanical Engineering·Adele ChangoorMichael D Buschmann
Jan 11, 2011·Osteoarthritis and Cartilage·H T KokkonenJ Töyräs
Mar 26, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Prashant N BansalMark W Grinstaff
Feb 22, 2012·Insights Into Imaging·Juergen FornaroPaul Stolzmann
Jun 1, 2012·PM & R : the Journal of Injury, Function, and Rehabilitation·David J Hunter, Ali Guermazi
Jul 10, 2012·Magnetic Resonance Imaging·Andriy FedorovRon Kikinis
Dec 6, 2012·Chemical Reviews·Hrvoje Lusic, Mark W Grinstaff
Dec 21, 2012·AJR. American Journal of Roentgenology·Esa K J TuominenKimmo T Mattila
Nov 20, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Harri T KokkonenJuha Töyräs
Jan 29, 2014·Contrast Media & Molecular Imaging·Carsten O SchirraEwald Roessl
May 6, 2014·Best Practice & Research. Clinical Rheumatology·Frank W RoemerAli Guermazi
Dec 2, 2014·Rheumatic Diseases Clinics of North America·David T Felson, Richard Hodgson
May 6, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Steven A OlsonFarshid Guilak
Jun 13, 2015·JACC. Cardiovascular Imaging·Ibrahim DanadJames K Min
Oct 1, 2012·Cartilage·Harri T KokkonenJuha Töyräs
Aug 25, 2015·Radiology·Cynthia H McColloughJoel G Fletcher
Nov 12, 2015·RMD Open·Marta FaveroLeonardo Punzi
May 1, 2016·Annals of Biomedical Engineering·Juuso T J HonkanenJuha Töyräs
Sep 21, 2016·Annals of Biomedical Engineering·Katariina A H MyllerJuha Töyräs
Dec 27, 2016·Journal of Magnetic Resonance Imaging : JMRI·Thomas M LinkXiaojuan Li
Mar 13, 2017·Journal of the Mechanical Behavior of Biomedical Materials·Abby E PetersRiaz Akhtar

❮ Previous
Next ❯

Citations

Sep 20, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Miitu K M HonkanenJuha Töyräs
Nov 7, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jonathan D FreedmanMark W Grinstaff
Jun 12, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Abhisek BhattaraiJuha Töyräs
Aug 9, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Abhisek BhattaraiMikael J Turunen
Oct 3, 2019·Annals of Biomedical Engineering·Miitu K M HonkanenJuha Töyräs
Mar 19, 2020·Frontiers in Bioengineering and Biotechnology·Satanik MukherjeeLiesbet Geris
Oct 27, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Brad B NelsonChris E Kawcak
May 14, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Annina E A SaukkoJuha Töyräs

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Software Mentioned

Slicer
DECT
Seg3D
MATLAB
3D

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.