Imaging of pulmonary disease in rheumatoid arthritis using J001X scintigraphy: preliminary results

European Journal of Nuclear Medicine
P GoupilleA Le Pape

Abstract

The purpose of this study was to determine the ability of technetium-99m J001X scintigraphy to image active pulmonary involvement in patients suffering from rheumatoid arthritis (RA). J001X is a fully characterized acylated poly(1,3)galactoside, isolated from Klebsiella membranes, which is able to bind recruited macrophages after aerosol administration. J001X scintigraphy was compared with high-resolution computed tomography (HRCT), pulmonary function tests (PFTs) and bronchoalveolar lavage (BAL) in 15 patients suffering from RA. Patients were considered to have pulmonary involvement when they had an interstitial syndrome on HRCT and a decrease of 20% in TCO/VE (transfer coefficient) on PFTs and/or an abnormal BAL (lymphocytosis higher than 20% and/or percentage of neutrophils higher than 10%). Pulmonary involvement was present in eight patients, and absent in seven. Of the eight patients with pulmonary involvement, all had abnormal BAL, two had an interstitial syndrome on HRCT, two had decreased TCO/VE and three had positive J001X scintigraphy. Of the seven patients without pulmonary involvement, six had normal BAL (not available in one), two had an interstitial syndrome on HRCT, one had decreased TCO/VE and two had positive J...Continue Reading

References

Nov 1, 1990·The American Review of Respiratory Disease·N L Müller, R R Miller
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May 2, 1980·JAMA : the Journal of the American Medical Association·P Cervantes-PerezP Rodriguez-Jurado
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Mar 1, 1993·The European Respiratory Journal·J E CotesJ C Yernault

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Citations

Aug 28, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Alberto SignoreFrancesco Scopinaro
Feb 24, 2001·The American Journal of the Medical Sciences·B R Gochuico
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Christophe Van de WieleRudi Andre Dierckx

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