Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans.

European Journal of Nuclear Medicine and Molecular Imaging
Swen HesseOsama Sabri

Abstract

[(11)C]DASB is currently the most frequently used highly selective radiotracer for visualization and quantification of central SERT. Its use, however, is hampered by the short half-life of (11)C, the moderate cortical test-retest reliability, and the lack of quantifying endogenous serotonin. Labelling with (18)F allows in principle longer acquisition times for kinetic analysis in brain tissue and may provide higher sensitivity. The aim of our study was to firstly use the new highly SERT-selective (18)F-labelled fluoromethyl analogue of (+)-McN5652 ((+)-[(18)F]FMe-McN5652) in humans and to evaluate its potential for SERT quantification. The PET data from five healthy volunteers (three men, two women, age 39 ± 10 years) coregistered with individual MRI scans were semiquantitatively assessed by volume-of-interest analysis using the software package PMOD. Rate constants and total distribution volumes (V (T)) were calculated using a two-tissue compartment model and arterial input function measurements were corrected for metabolite/plasma data. Standardized uptake region-to-cerebellum ratios as a measure of specific radiotracer accumulation were compared with those of a [(11)C]DASB PET dataset from 21 healthy subjects (10 men, 11 wom...Continue Reading

References

Mar 4, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A BuckC Burger
Aug 22, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P BrustO Sabri
Sep 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marion KretzschmarBernd Johannsen
Nov 6, 2004·Neuroscience and Biobehavioral Reviews·Swen HesseUlrich Müller
Oct 11, 2005·Psychiatry Research·Swen HesseKatarina Stengler-Wenzke
Jun 1, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R Todd OgdenRamin V Parsey
Aug 11, 2007·Psychopharmacology·Ursula F BailerWalter H Kaye
Dec 14, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Masanobu IbarakiMasaharu Amano
Oct 13, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Ya-Yao HuangChyng-Yann Shiue
Jan 15, 2011·The International Journal of Neuropsychopharmacology·Swen HesseOsama Sabri

❮ Previous
Next ❯

Citations

Jan 10, 2016·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Cheng-Yi ChengChyng-Yann Shiue
Sep 17, 2013·Nuclear Medicine and Biology·Lin ZhuHank F Kung
Sep 10, 2016·The International Journal of Eating Disorders·A BreschS Hesse
Apr 14, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Martin NørgaardGitte M Knudsen
Jan 10, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Swen HesseOsama Sabri
Sep 27, 2019·Future Medicinal Chemistry·Maria D MatveevaCosimo D Altomare
Mar 21, 2017·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·E C C CastroC Galambos
Jul 30, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Peter BrustOsama Sabri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Related Papers

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Ya-Yao HuangChyng-Yann Shiue
European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Marion KretzschmarBernd Johannsen
Nuclear Medicine and Biology
René HummerichRalph Buchert
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Rainer HinzPaul M Grasby
© 2022 Meta ULC. All rights reserved