Imaging outcome measures of neuroprotection and repair in MS: A consensus statement from NAIMS

Neurology
Jiwon OhNorth American Imaging in Multiple Sclerosis Cooperative

Abstract

To summarize current and emerging imaging techniques that can be used to assess neuroprotection and repair in multiple sclerosis (MS), and to provide a consensus opinion on the potential utility of each technique in clinical trial settings. Clinicians and scientists with expertise in the use of MRI in MS convened in Toronto, Canada, in November 2016 at a North American Imaging in Multiple Sclerosis (NAIMS) Cooperative workshop meeting. The discussion was compiled into a manuscript and circulated to all NAIMS members in attendance. Edits and feedback were incorporated until all authors were in agreement. A wide spectrum of imaging techniques and analysis methods in the context of specific study designs were discussed, with a focus on the utility and limitations of applying each technique to assess neuroprotection and repair. Techniques were discussed under specific themes, and included conventional imaging, magnetization transfer ratio, diffusion tensor imaging, susceptibility-weighted imaging, imaging cortical lesions, magnetic resonance spectroscopy, PET, advanced diffusion imaging, sodium imaging, multimodal techniques, imaging of special regions, statistical considerations, and study design. Imaging biomarkers of neuroprotec...Continue Reading

References

Jun 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A MacKayD Graeb
Oct 29, 2002·Annals of Neurology·Alberto CifelliPaul M Matthews
Sep 7, 2004·Annals of Neurology·Klaus SchmiererDavid H Miller
Sep 7, 2007·Journal of Neuropathology and Experimental Neurology·Jeroen J G GeurtsPaul van der Valk
Feb 8, 2008·Annals of Neurology·Jacqueline T ChenUNKNOWN Canadian MS/BMT Study Group
Mar 11, 2009·Archives of Neurology·Paul S GiacominiDouglas L Arnold
Jun 3, 2009·Nature Reviews. Neurology·Frederik BarkhofStephen C Reingold
Dec 3, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ludovic de RochefortYi Wang
Jul 1, 2010·Acta Neurologica Scandinavica. Supplementum·L J StovnerJ A Zwart
Oct 16, 2010·AJNR. American Journal of Neuroradiology·R J FoxM D Phillips
Jun 29, 2011·Annals of Neurology·María I GaitánDaniel S Reich
Dec 14, 2011·NeuroImage·Shannon KolindJackie Palace
Oct 3, 2012·Nature Reviews. Neurology·Robin J M FranklinKenneth J Smith
Apr 5, 2013·Journal of Magnetic Resonance Imaging : JMRI·Sandra M MeyersCornelia Laule
Jun 14, 2013·Neurology·Vanessa WiggermannAlexander Rauscher
Jul 23, 2013·Annals of Neurology·Simon HametnerHans Lassmann
Jun 20, 2014·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Rezwan GhassemiDouglas L Arnold
Aug 5, 2014·Annals of Neurology·Regina SchlaegerRoland G Henry
Nov 8, 2014·NeuroImage. Clinical·Russell T ShinoharaUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 17, 2015·Lancet Neurology·Don H MahadHans Lassmann
Oct 1, 2013·Multiple Sclerosis and Related Disorders·M IngleseL Fleysher
Apr 17, 2015·Multiple Sclerosis and Related Disorders·D R AltmannD H Miller
Jul 21, 2015·Annals of Neurology·Shiv SaidhaPeter A Calabresi
Nov 26, 2015·NeuroImage. Clinical·Wendy S VargasSusan A Gauthier
Mar 10, 2016·Brain : a Journal of Neurology·Iris D KilsdonkJeroen J G Geurts
Mar 19, 2016·PloS One·Tobias Djamsched FaizySusanne Siemonsen
Jun 9, 2016·The Journal of Clinical Investigation·Martina AbsintaDaniel S Reich
Nov 1, 2016·Acta Neuropathologica·Assunta Dal-BiancoSimon Hametner
Nov 5, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Robert ZivadinovBianca Weinstock-Guttman
Jan 13, 2017·Magnetic Resonance Imaging·Thanh D NguyenYi Wang

❮ Previous
Next ❯

Citations

May 28, 2020·ELife·Jennifer Orthmann-MurphyDwight E Bergles
Aug 1, 2019·Biomedicines·Gabrielle Macaron, Daniel Ontaneda
Jul 1, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Chenyu WangMichael Harry Barnett
Jul 15, 2021·Journal of Magnetic Resonance Imaging : JMRI·Angelika B MenneckeArnd Doerfler
Jul 31, 2021·Journal of Magnetic Resonance Imaging : JMRI·Tomohisa Okada, Thai Akasaka
May 21, 2021·Neurodegenerative Disease Management·Andrea M Kuczynski, Jiwon Oh
Aug 15, 2021·Annals of Neurology·Hadar KolbDaniel S Reich
Jan 11, 2022·Translational Vision Science & Technology·Samuel KlistornerAlexander Klistorner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.