PMID: 15218808Jun 29, 2004Paper

Imaging primary progressive multiple sclerosis: the contribution of structural, metabolic, and functional MRI techniques

Multiple Sclerosis : Clinical and Laboratory Research
Massimo FilippiMaria A Rocca

Abstract

Patients with primary progressive multiple sclerosis (PPMS) typically experience a progressive disease course from onset, leading to the accumulation of severe neurological disability. This is in contrast with the observation that the burden and activity of lesions on conventional magnetic resonance imaging (MRI) scans of the brain are much lower in patients with PPMS than in those with other less disabling forms of the disease. Studies with structural and functional MRI techniques are providing relevant contributions to the understanding of the mechanisms underlying the accumulation of irreversible neurological deficits in patients with PPMS. The results of these studies underpin that the main factors possibly explaining the clinical/MRI discrepancy observed in patients with PPMS include the presence of a diffuse tissue damage that is beyond the resolution of conventional imaging, the extent of cervical cord damage, and the impairment of the adaptive capacity of the cortex to limit the functional consequences of subcortical pathology.

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Citations

May 17, 2005·Physical Medicine and Rehabilitation Clinics of North America·Jack H Simon
Mar 4, 2014·Radiologic Clinics of North America·Timothy R MillerGaurav Jindal
Feb 24, 2016·International Journal of Biomedical Imaging·Roey MechrezHayit Greenspan
Mar 29, 2011·Neurologic Clinics·Kathleen Hawker
Nov 3, 2007·Journal of the Neurological Sciences·Douglas R DenneyBrett A Parmenter
Sep 22, 2007·Lancet Neurology·David H Miller, Siobhan M Leary
Jul 29, 2006·Magnetic Resonance Imaging Clinics of North America·Jack H Simon
Nov 22, 2005·Radiologic Clinics of North America·Jack H Simon
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Sep 26, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Giancarlo Comi
Apr 22, 2010·Neurological Research·Simona CarrubbaAndrew A Marino
May 5, 2021·Annals of Clinical and Translational Neurology·Matthew R BrierRobert T Naismith
Aug 28, 2021·Brain Sciences·Parvathi Menon, Steve Vucic

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